Case Study #4

May 2017

A 71 year old HIV-negative diabetic female former smoker with a history of breast cancer: experiences nausea and abdominal pain as well as occasional bloody diarrhea, along with gradual weight loss over the span of three months. An endoscopy showed an ulcerated and bleeding lesion about 4 cm in size in the ileum, not accessible to endoscopic biopsy. After an FDG-PET scan and consultation, the patient underwent surgical resection of the area of increased uptake as well as proximal lymph nodes. Histopathology stains were made of the resected lesions and the results are below.
What is the diagnosis?