Cytokeratin 7 (OV-TL 12/30) Mouse Monoclonal Antibody

Cytokeratin 7
Lung adenocarcinoma is strongly and diffusely positive for cytokeratin 7 antibody.

Cytokeratin 7 (OV-TL 12/30) Mouse Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-05-24 08:46:09

Anti-cytokeratin 7 reacts with proteins that are found in most ductal, glandular, transitional, and biliary duct epithelial cells. Cytokeratin 7 (CK7) labeling can help distinguish between lung,1 breast carcinomas, and urothelial carcinomas that typically stain positive, and colon and prostate carcinomas that typically lack CK7 expression.2-7 CK 7 is a common marker of primary lung adenocarcinomas (almost all cases) with a lower specificity since it is also observed in other primary lung carcinomas and non-pulmonary carcinomas.1 Anti-cytokeratin 7 has also been useful in the differential diagnosis of ovarian neoplasms.8 This antibody does not recognize intermediate filament proteins.

  1. Jerome MV, et al. Histopathology. 2004; 45:125-34.
  2. Murray SK, et al. Am J Surg Pathol. 2004; 28:1154-62.
  3. Chu P, et al. Mod Pathol. 2000; 13:962-72.
  4. Logani S, et al. Am J Surg Pathol. 2003; 27:1434-41.
  5. Ramalingam P, et al. Ann Diagn Pathol. 2003; 7:112-9.
  6. Roy S, et al. Arch Pathol Lab Med. 2011; 135:1601-5.
  7. Han AC, et al. Cancer. 1999; 86:2327-30.
  8. McCluggage WG, et al. Histopathology. 2005; 47:231-247.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: salivary gland, lung adenocarcinoma
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

25 mL predilute307M-90
0.1 mL concentrate307M-94
0.5 mL concentrate307M-95
1 mL concentrate307M-96
1 mL predilute307M-97
7 mL predilute307M-98

For in vitro diagnostic (IVD) use in Canada

25 mL predilute307M-90
0.1 mL concentrate307M-94
0.5 mL concentrate307M-95
1 mL concentrate307M-96
1 mL predilute307M-97
7 mL predilute307M-98

For in vitro diagnostic (IVD) use in Europe

25 mL predilute307M-90
0.1 mL concentrate307M-94
0.5 mL concentrate307M-95
1 mL concentrate307M-96
1 mL predilute307M-97
7 mL predilute307M-98

For research use only (RUO) in Japan

25 mL predilute307M-90-RUO
0.1 mL concentrate307M-94-RUO
0.5 mL concentrate307M-95-RUO
1 mL concentrate307M-96-RUO
1 mL predilute307M-97-RUO
7 mL predilute307M-98-RUO

 

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