Desmin (D33) Mouse Monoclonal Antibody

Desmin
Desmin antibody stains smooth muscle in a cytoplasmic pattern.

Desmin (D33) Mouse Monoclonal Antibody

Specialties: Soft Tissue Pathology

Updated: 2017-05-24 08:46:09

Anti-desmin detects a protein that is expressed by cells of normal smooth, skeletal, and cardiac muscles. It has been suggested that desmin is primarily located at or near the periphery of Z lines in striated muscle fibrils.1 In smooth muscle, desmin interconnects cytoplasmic dense bodies with membrane bound dense plaques. Anti-desmin reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.1-4 This antibody is used to demonstrate the myogenic components/derivation of tumors.2,3 Desmin can also be present in myofibroblasts and be focally positive in desmoid fibromatosis.4

  1. Kouloumenta A, et al. Proper perinuclear localization of the TRIM-like protein myospryn requires its binding partner desmin. Journal of Biological Chemistry. 2007; 282:35211-21.
  2. Altmannsberger M, et al. Desmin is a specific marker for rhabdomyosarcomas of human and rat origin. Am J Pathol 1985; 118:85-95.
  3. Debus E, et al. Monoclonal antibodies to desmin, the muscle-specific intermediate filament protein. EMBO J. 1983; 2:2305-12.
  4. Yamaguchi U, et al. Differential diagnosis of gastrointestinal stromal tumor and other spindle cell tumors in the gastrointestinal tract based on immunohistochemical analysis. Virchows Arch. 2004; 2:142-50.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: skeletal muscle
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate243M-14
0.5 mL concentrate243M-15
1 mL concentrate243M-16
1 mL predilute243M-17
7 mL predilute243M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate243M-14
0.5 mL concentrate243M-15
1 mL concentrate243M-16
1 mL predilute243M-17
7 mL predilute243M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate243M-14
0.5 mL concentrate243M-15
1 mL concentrate243M-16
1 mL predilute243M-17
7 mL predilute243M-18

For research use only (RUO) in Japan

0.1 mL concentrate243M-14-RUO
0.5 mL concentrate243M-15-RUO
1 mL concentrate243M-16-RUO
1 mL predilute243M-17-RUO
7 mL predilute243M-18-RUO

 

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