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Microphthalmia Transcription Factor (MiTF) (C5/D5)

Mouse Monoclonal


Microphthalmia (MiTF) is a transcription factor implicated in pigmentation, bone development and in mast cells. Various forms of MiTF exist ranging from 50-70 kD in size. This antibody targets the 52-56 kD range. This antibody has been useful in identifying malignant melanoma, and distinguishing mast cell lesions from lesions of myeloid derivation. A relatively rare class of tumors known as PEComas (tumors showing perivascular epithelioid cell differentiation) express MiTF in a high percentage of cases (~90%).

Specialties: Dermatopathology

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: melanoma
  • Isotype: IgG1 & IgG1
  • Dilution Range: 1:100-1:500*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Leica Bond
    Protocol J: ER2/20
  • Leica Bond
    Protocol F: ER2/20
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

Package Inserts


IFU SDS

References


  1. Liegl B, et al. Am J Surg Pathol. 2008; 32:608-14.
  2. Righi A, et al. Int J Surg Pathol. 2008; 16:16-20.
  3. Weinreb I, et al. Virchows Arch. 2007; 450:463-70.
  4. Ohsie SJ, et al. J Cutan Pathol. 2008; 35:433-44.
  5. Hornick JL, et al. Am J Surg Pathol. 2008; 32:493-501.

Last updated: 2017-05-24 08:46:09

Microphthalmia Transcription Factor (MiTF)
Anti-MiTF labels the nucleus and cytoplasm of tumor cells in melanoma.

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Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: melanoma
  • Isotype: IgG1 & IgG1
  • Dilution Range: 1:100-1:500*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Leica Bond
    Protocol J: ER2/20
  • Leica Bond
    Protocol F: ER2/20
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

References


  1. Liegl B, et al. Am J Surg Pathol. 2008; 32:608-14.
  2. Righi A, et al. Int J Surg Pathol. 2008; 16:16-20.
  3. Weinreb I, et al. Virchows Arch. 2007; 450:463-70.
  4. Ohsie SJ, et al. J Cutan Pathol. 2008; 35:433-44.
  5. Hornick JL, et al. Am J Surg Pathol. 2008; 32:493-501.

Package Inserts

Select revision:



Ordering Information

For in vitro diagnostic (IVD) use in USA

25 mL predilute 284M-90
0.1 mL concentrate 284M-94
0.5 mL concentrate 284M-95
1 mL concentrate 284M-96
1 mL predilute 284M-97
7 mL predilute 284M-98

For in vitro diagnostic (IVD) use in Canada

25 mL predilute 284M-90
0.1 mL concentrate 284M-94
0.5 mL concentrate 284M-95
1 mL concentrate 284M-96
1 mL predilute 284M-97
7 mL predilute 284M-98

For in vitro diagnostic (IVD) use in Europe

25 mL predilute 284M-90
0.1 mL concentrate 284M-94
0.5 mL concentrate 284M-95
1 mL concentrate 284M-96
1 mL predilute 284M-97
7 mL predilute 284M-98

For research use only (RUO) in Japan

25 mL predilute 284M-90-RUO
0.1 mL concentrate 284M-94-RUO
0.5 mL concentrate 284M-95-RUO
1 mL concentrate 284M-96-RUO
1 mL predilute 284M-97-RUO
7 mL predilute 284M-98-RUO

 

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Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: melanoma
  • Isotype: IgG1 & IgG1
  • Dilution Range: 1:100-1:500*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Leica Bond
    Protocol J: ER2/20
  • Leica Bond
    Protocol F: ER2/20
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

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References


  1. Liegl B, et al. Am J Surg Pathol. 2008; 32:608-14.
  2. Righi A, et al. Int J Surg Pathol. 2008; 16:16-20.
  3. Weinreb I, et al. Virchows Arch. 2007; 450:463-70.
  4. Ohsie SJ, et al. J Cutan Pathol. 2008; 35:433-44.
  5. Hornick JL, et al. Am J Surg Pathol. 2008; 32:493-501.
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