Cytokeratin Cocktail (AE1 & AE3) Mouse Monoclonal Antibody

Cytokeratin Cocktail
Cytokeratin Cocktail (AE1 & AE3) on colon.

Cytokeratin Cocktail (AE1 & AE3) Mouse Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-05-24 08:46:09

Anti-cytokeratin cocktail (AE1 & AE3) is the broad-spectrum keratin antibody cocktail.1-3 It is composed of mouse monoclonal antibody AE1 that recognizes the acidic type I keratins 10, 14, 15, 16, 19, and AE3 that reacts with the basic type II keratins 1, 2, 3, 4, 5, 6, 7, and 8. Both clones were generated using epidermal keratin as immunogen.1-3 This antibody detects carcinomas of different organ origin, but is most frequently negative in hepatocellular carcinoma, chromophobe RCC, adrenol cortical carcinoma, some clear cell renal cell carcinomas, and renal oncocytoma.1,2 This antibody cocktail can cross-react with other intermediate filaments, such as glial fibrillary acidic protein, giving a false-positive staining in glial tumors.4

  1. Battifora H. Clinical applications of the immunohistochemistry of filamentous proteins. Am J Surg Pathol. 1988; 12:24.
  2. Cooper D, et al. Classification of human epithelia and their neoplasms using monoclonal antibodies to keratins: strategies, applications, and limitations. Lab Invest. 1985; 52:243-56.
  3. Gown AM, et al. Monoclonal antibodies to human intermediate filament proteins. III. Analysis of tumors. AM J Clin Pathol. 1985; 84:413.
  4. Kriho UK, et al. Keratin expression in astrocytomas: An immunofluorescent and biochemical reassessment. Virehows Arch. 1997; 431:139-47.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: breast, lung, colon, skin
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

25 mL predilute313M-10
0.1 mL concentrate313M-14
0.5 mL concentrate313M-15
1 mL concentrate313M-16
1 mL predilute313M-17
7 mL predilute313M-18

For in vitro diagnostic (IVD) use in Canada

25 mL predilute313M-10
0.1 mL concentrate313M-14
0.5 mL concentrate313M-15
1 mL concentrate313M-16
1 mL predilute313M-17
7 mL predilute313M-18

For in vitro diagnostic (IVD) use in Europe

25 mL predilute313M-10
0.1 mL concentrate313M-14
0.5 mL concentrate313M-15
1 mL concentrate313M-16
1 mL predilute313M-17
7 mL predilute313M-18

For research use only (RUO) in Japan

25 mL predilute313M-10-RUO
0.1 mL concentrate313M-14-RUO
0.5 mL concentrate313M-15-RUO
1 mL concentrate313M-16-RUO
1 mL predilute313M-17-RUO
7 mL predilute313M-18-RUO

 

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