HMB-45 (HMB-45) Mouse Monoclonal Antibody

HMB-45
HMB-45 expression is found in the cytoplasm of the melanoma cells by anti-HMB-45.

HMB-45 (HMB-45) Mouse Monoclonal Antibody

Specialties: Dermatopathology

Updated: 2017-05-24 08:46:09

Anti-HMB45 is a useful melanoma immunohistochemical marker that reacts with antigens present on immature melanosomes. Anti-HMB45 is useful for identifying amelanotic melanoma from other neoplastic lesions with similar morphology.1-5

  1. Gown AM, et al. Monoclonal antibodies specific for melanocytic tumors distinguish subpopulations of melanocytes. Am J Pathol. 1986; 123:195-203.
  2. Wick MR, et al. Immunohistochemical diagnosis of sinonasal melanoma, carcinoma, and neuroblastoma with monoclonal antibodies HMB-45 and anti-synaptophysin. Arch Pathol Lab Med. 1988; 112:616-20.
  3. Abrahamsen HN, et al. Sentinel lymph nodes in malignant melanoma: extended histopathologic evaluation improves diagnostic precision. Cancer. 2004; 100:1683-91.
  4. Vaggelli L, et al. Radioisotopic lymphatic mapping of the sentinel node in melanoma: importance of immunohistochemistry. Tumori. 2000; 86:346-8.
  5. Baisden BL, et al. HMB-45 immunohistochemical staining of sentinel lymph nodes: a specific method for enhancing detection of micrometastases in patients with melanoma. Am J Surg Pathol. 2000; 24:1140-6.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: melanoma
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate282M-94
0.5 mL concentrate282M-95
1 mL concentrate282M-96
1 mL predilute282M-97
7 mL predilute282M-98

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate282M-94
0.5 mL concentrate282M-95
1 mL concentrate282M-96
1 mL predilute282M-97
7 mL predilute282M-98

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate282M-94
0.5 mL concentrate282M-95
1 mL concentrate282M-96
1 mL predilute282M-97
7 mL predilute282M-98

For research use only (RUO) in Japan

0.1 mL concentrate282M-94-RUO
0.5 mL concentrate282M-95-RUO
1 mL concentrate282M-96-RUO
1 mL predilute282M-97-RUO
7 mL predilute282M-98-RUO

 

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