Cytokeratin 8 & 18 (B22.1 & B23.1) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology
Cytokeratins 8 &18 (CK 8 & 18) are expressed in most simple epithelia (e.g. thyroid, breast, gastrointestinal tract, and respiratory tract). Anti-CK 8 & 18 have been reported to stain most adenocarcinomas and squamous cell carcinomas, but not some well-differentiated squamous cell carcinomas.1-3 Cytokeratin 8 & 18 have been reported to be useful markers for identifying Paget cells,4 colorectal carcinoma metastases,5 and gastric cancer micrometastases.6
- Angus B, et al. NCL-5D3: a new monoclonal antibody recognizing low molecular weight cytokeratins effective for immunohistochemistry using fixed paraffin-embedded tissue. J Pathol. 1987; 155:377-84.
- Corson, JM. Keratin protein immunohistochemistry in surgical pathology practice. Pathol Annu. 1986; 21:47-81.
- Moll R, et al. The human keratins: biology and pathology. Histochem Cell Biol. 2008; 129:705-33.
- Liegl B, et al. Mammary and extramammary Paget's disease: an immunohistochemical study of 83 cases. Histopathology. 2007; 50:439-47.
- Sasaki M, et al. Immunoperoxidase staining for cytokeratins 8 and 18 is very sensitive for detection of occult node metastasis of colorectal cancer: a comparison with genetic analysis of K-ras. Histopathology. 1998; 32:199-208.
- Ishii et al. Detection of sentinel and non-sentinel lymph node micrometastases by complete serial sectioning and immunohistochemical analysis for gastric cancer. J Exp Clin Cancer Res. 2008; 27:7.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic
- Control: prostate, pancreas
- Dilution Range: 1:100-1:500*
Package Inserts
IFU
- IVD Rev. 7.0 (CMC81829070)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25 mL predilute | 818M-90 |
| 0.1 mL concentrate | 818M-94 |
| 0.5 mL concentrate | 818M-95 |
| 1 mL concentrate | 818M-96 |
| 1 mL predilute | 818M-97 |
| 7 mL predilute | 818M-98 |
For in vitro diagnostic (IVD) use in Canada
| 25 mL predilute | 818M-90 |
| 0.1 mL concentrate | 818M-94 |
| 0.5 mL concentrate | 818M-95 |
| 1 mL concentrate | 818M-96 |
| 1 mL predilute | 818M-97 |
| 7 mL predilute | 818M-98 |
For in vitro diagnostic (IVD) use in Europe
| 25 mL predilute | 818M-90 |
| 0.1 mL concentrate | 818M-94 |
| 0.5 mL concentrate | 818M-95 |
| 1 mL concentrate | 818M-96 |
| 1 mL predilute | 818M-97 |
| 7 mL predilute | 818M-98 |
For research use only (RUO) in Japan
| 25 mL predilute | 818M-90-RUO |
| 0.1 mL concentrate | 818M-94-RUO |
| 0.5 mL concentrate | 818M-95-RUO |
| 1 mL concentrate | 818M-96-RUO |
| 1 mL predilute | 818M-97-RUO |
| 7 mL predilute | 818M-98-RUO |
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