Cytokeratin 8 & 18 (B22.1 & B23.1) Mouse Monoclonal Antibody

Cytokeratin 8 & 18
Ducts and acini of the salivary gland are labelled by anti-cytokeratin 8 & 18 in a cytoplasmic reaction.

Cytokeratin 8 & 18 (B22.1 & B23.1) Mouse Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-05-24 08:46:09

Cytokeratins 8 &18 (CK 8 & 18) are expressed in most simple epithelia (e.g. thyroid, breast, gastrointestinal tract, and respiratory tract). Anti-CK 8 & 18 have been reported to stain most adenocarcinomas and squamous cell carcinomas, but not some well-differentiated squamous cell carcinomas.1-3  Cytokeratin 8 & 18 have been reported to be useful markers for identifying Paget cells,4 colorectal carcinoma metastases,5 and gastric cancer micrometastases.6

  1. Angus B, et al. NCL-5D3: a new monoclonal antibody recognizing low molecular weight cytokeratins effective for immunohistochemistry using fixed paraffin-embedded tissue. J Pathol. 1987; 155:377-84.
  2. Corson, JM. Keratin protein immunohistochemistry in surgical pathology practice. Pathol Annu. 1986; 21:47-81.
  3. Moll R, et al. The human keratins: biology and pathology. Histochem Cell Biol. 2008; 129:705-33.
  4. Liegl B, et al. Mammary and extramammary Paget's disease: an immunohistochemical study of 83 cases. Histopathology. 2007; 50:439-47.
  5. Sasaki M, et al. Immunoperoxidase staining for cytokeratins 8 and 18 is very sensitive for detection of occult node metastasis of colorectal cancer: a comparison with genetic analysis of K-ras. Histopathology. 1998; 32:199-208.
  6. Ishii et al. Detection of sentinel and non-sentinel lymph node micrometastases by complete serial sectioning and immunohistochemical analysis for gastric cancer. J Exp Clin Cancer Res. 2008; 27:7.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: prostate, pancreas
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

25 mL predilute818M-90
0.1 mL concentrate818M-94
0.5 mL concentrate818M-95
1 mL concentrate818M-96
1 mL predilute818M-97
7 mL predilute818M-98

For in vitro diagnostic (IVD) use in Canada

25 mL predilute818M-90
0.1 mL concentrate818M-94
0.5 mL concentrate818M-95
1 mL concentrate818M-96
1 mL predilute818M-97
7 mL predilute818M-98

For in vitro diagnostic (IVD) use in Europe

25 mL predilute818M-90
0.1 mL concentrate818M-94
0.5 mL concentrate818M-95
1 mL concentrate818M-96
1 mL predilute818M-97
7 mL predilute818M-98

For research use only (RUO) in Japan

25 mL predilute818M-90-RUO
0.1 mL concentrate818M-94-RUO
0.5 mL concentrate818M-95-RUO
1 mL concentrate818M-96-RUO
1 mL predilute818M-97-RUO
7 mL predilute818M-98-RUO

 

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