Cytokeratin 20 (Ks20.8) Mouse Monoclonal Antibody

Cytokeratin 20
Cytokeratin 20 (Ks20.8) on colon.

Cytokeratin 20 (Ks20.8) Mouse Monoclonal Antibody

Specialties: Anatomic Pathology

Updated: 2017-05-24 08:46:09

Cytokeratin 20 is a 46-kDa intermediate filament protein which reacts primarily with gastric and intestinal epithelium, urothelium, and Merkel cells.1-4 Anti-Cytokeratin 20 is useful in the identification of specific types of these epithelial cells under normal hyperplastic and neoplastic conditions.3 Cytokeratin 20 has been detected in adenocarcinomas of the colon, stomach and biliary tract.5-7 Merkel cell carcinomas have shown reactivity. In contrast, carcinomas of the breast are generally non-reactive.

  1. Moll R, et al. Identification of protein IT of the intestinal cytoskeleton as a novel type 1 cytokeratin with unusual properties and expression patterns. J Cell Biol. 1990; 111:567-80.
  2. Moll R, et al. The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell. 1982; 31:11-24.
  3. Han AC, Duszak R Jr. Coexpression of cytokeratins 7 and 20 confirms urothelial carcinoma presenting as an intrarenal tumor. Cancer. 1999; 86:2327-30.
  4. Moll R, et al. Cytokeratin 20 in human carcinomas: a new histodiagnostic marker detected by monoclonal antibodies. AJP. 1992; 140:427-47.
  5. Tot T. Adenocarcinomas metastatic to the liver: the value of cytokeratins 20 and 7 in search for unknown primary tumors. Cancer 1999; 85:171-7.
  6. Lau SK, et al. Comparative immunohistochemical profile of hepatocellular carcinoma, cholangiocarcinoma, and metastatic adenocarcinoma. Hum Pathol. 2002; 33:1175-81.
  7. Rullier A et al. Cytokeratin 7 and 20 expression in cholangiocarcinomas varies along the biliary tract but still differs from that in colorectal carcinoma metastasis. Am J Surg Pathol. 2000; 24:870-6.

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic
  • Control: colon carcinoma
  • Dilution Range: 1:200-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

25 mL predilute320M-10
0.1 mL concentrate320M-14
0.5 mL concentrate320M-15
1 mL concentrate320M-16
1 mL predilute320M-17
7 mL predilute320M-18

For in vitro diagnostic (IVD) use in Canada

25 mL predilute320M-10
0.1 mL concentrate320M-14
0.5 mL concentrate320M-15
1 mL concentrate320M-16
1 mL predilute320M-17
7 mL predilute320M-18

For in vitro diagnostic (IVD) use in Europe

25 mL predilute320M-10
0.1 mL concentrate320M-14
0.5 mL concentrate320M-15
1 mL concentrate320M-16
1 mL predilute320M-17
7 mL predilute320M-18

For research use only (RUO) in Japan

25 mL predilute320M-10-RUO
0.1 mL concentrate320M-14-RUO
0.5 mL concentrate320M-15-RUO
1 mL concentrate320M-16-RUO
1 mL predilute320M-17-RUO
7 mL predilute320M-18-RUO

 

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