SOX-10 Rabbit Polyclonal Antibody
Specialties: Dermatopathology
Sry-related HMG-BOX gene 10, SOX-10, is a transcription factor involved in neural crest and peripheral nervous system development, and acts as a nucleocytoplasmic shuttle protein.1 SOX-10 is expressed in melanocytic lineages, and is a sensitive marker of melanoma for conventional, and desmoplastic subtypes.2-3 In normal tissues, SOX-10 is expressed in melanocytes, and myoepithelial cells.4
- Rehberg S, et al. Sox10 is an active nucleocytoplasmic shuttle protein, and shuttling is crucial for Sox10-mediated transactivation. Mol Cell Biol. 2002; 22:5826-34.
- Nonaka D, et al. Sox10: a pan-schwannian and melanocytic marker. Am J Surg Pathol. 2008; 32:1291-8.
- Karamchandani, et al. Sox10 and S100 in the diagnosis of soft-tissue neoplasms. Appl Immunohistochem Mol Morphol. 2012; 20:445-50.
- Miettinen M, et al. Sox10--a marker for not only schwannian and melanocytic neoplasms but also myoepithelial cell tumors of soft tissue: a systematic analysis of 5134 tumors. Am J Surg Pathol. 2015; 39:826-35.
Specifications
- Reactivity: paraffin
- Control: Melanoma (Nuclear); Schwannoma (Nuclear); Skin Melanocytes (Nuclear)
- Dilution Range: 1:25-1:100 *
Package Inserts
IFU
- IVD Rev. 4.0 (CMC38317040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
0.1 mL concentrate | 383A-74 |
0.5 mL concentrate | 383A-75 |
1.0 mL concentrate | 383A-76 |
1.0 mL predilute ready-to-use | 383A-77 |
7.0 mL predilute ready-to-use | 383A-78 |
For in vitro diagnostic (IVD) use in Canada
0.1 mL concentrate | 383A-74 |
0.5 mL concentrate | 383A-75 |
1.0 mL concentrate | 383A-76 |
1.0 mL predilute ready-to-use | 383A-77 |
7.0 mL predilute ready-to-use | 383A-78 |
For in vitro diagnostic (IVD) use in Europe
0.1 mL concentrate | 383A-74 |
0.5 mL concentrate | 383A-75 |
1.0 mL concentrate | 383A-76 |
1.0 mL predilute ready-to-use | 383A-77 |
7.0 mL predilute ready-to-use | 383A-78 |
For research use only (RUO) in Japan
0.1 mL concentrate (RUO) | 383A-74-RUO |
0.5 mL concentrate (RUO) | 383A-75-RUO |
1.0 mL concentrate (RUO) | 383A-76-RUO |
1.0 mL predilute ready-to-use (RUO) | 383A-77-RUO |
7.0 mL predilute ready-to-use (RUO) | 383A-78-RUO |
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