SOX-10 Rabbit Polyclonal Antibody

SOX-10
Nuclear labelling of melanoma tumor cells by SOX-10 antibody.

SOX-10 Rabbit Polyclonal Antibody

Specialties: Dermatopathology

Updated: 2017-05-24 08:46:09

Sry-related HMG-BOX gene 10, SOX-10, is a transcription factor involved in neural crest and peripheral nervous system development, and acts as a nucleocytoplasmic shuttle protein.1  SOX-10 is expressed in melanocytic lineages, and is a sensitive marker of melanoma for conventional, and desmoplastic subtypes.2-3 In normal tissues, SOX-10 is expressed in melanocytes, and myoepithelial cells.4

  1. Rehberg S, et al. Sox10 is an active nucleocytoplasmic shuttle protein, and shuttling is crucial for Sox10-mediated transactivation. Mol Cell Biol. 2002; 22:5826-34.
  2. Nonaka D, et al. Sox10: a pan-schwannian and melanocytic marker. Am J Surg Pathol. 2008; 32:1291-8.
  3. Nielsen TO, et al. Sox10 and S100 in the diagnosis of soft-tissue neoplasms. Appl Immunohistochem Mol Morphol. 2012; 20:445-50.
  4. Miettinen M, et al. Sox10--a marker for not only schwannian and melanocytic neoplasms but also myoepithelial cell tumors of soft tissue: a systematic analysis of 5134 tumors. Am J Surg Pathol. 2015; 39:826-35.

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: melanoma, schwannoma, skin melanocytes
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate383A-74
0.5 mL concentrate383A-75
1 mL concentrate383A-76
1 mL predilute383A-77
7 mL predilute383A-78

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate383A-74
0.5 mL concentrate383A-75
1 mL concentrate383A-76
1 mL predilute383A-77
7 mL predilute383A-78

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate383A-74
0.5 mL concentrate383A-75
1 mL concentrate383A-76
1 mL predilute383A-77
7 mL predilute383A-78

For research use only (RUO) in Japan

0.1 mL concentrate383A-74-RUO
0.5 mL concentrate383A-75-RUO
1 mL concentrate383A-76-RUO
1 mL predilute383A-77-RUO
7 mL predilute383A-78-RUO

 

To request information on this product in additional countries, please click the button below.

Request More Information