Cell Marque Portfolio

CDX-2 (EPR2764Y)

Rabbit Monoclonal


CDX-2 is a caudal-related homeobox transcription factor whose expression in the adult is normally present in the gastrointestinal (GI) epithelium.1 It is implicated in the development and maintenance of the intestinal mucosa.2 This protein is expressed immunohistochemically in the nuclei of normal GI epithelium.1 CDX-2 protein expression has been seen in GI carcinomas. Anti-CDX-2 has been useful to establish GI origin of metastatic adenocarcinomas and carcinoids2,3 and is especially useful to distinguish metastatic colorectal adenocarcinoma from lung adenocarcinoma.1,4,5,6,7 However, mucinous carcinomas of the ovary also stain positively with this antibody, which limits the usefulness of this marker in the distinction of metastatic colorectal adenocarcinoma versus mucinous carcinoma of the ovary.8

Specialties: Anatomic Pathology Gastrointestinal (GI) Pathology

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: colon
  • Isotype: IgG
  • Dilution Range: 1:100-1:500*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

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References


  1. Mazziotta RM, et al. Appl Immunohistochem Mol Morphol. 2005; 13:55-60.
  2. Erickson LA, et al. Endocr Pathol. 2004; 15:247-52.
  3. Saqi A, et al. Am J Clin Pathol. 2005; 123:394-404.
  4. Saad RS, et al. Am J Clin Pathol. 2004; 122:421-7.
  5. Kaimaktchiev V, et al. Mod Pathol. 2004; 17:1392-9.
  6. Werling RW, et al. Am J Surg Pathol. 2003; 27:303-10.
  7. Groisman GM, et al. Int J Gynecol Pathol. 2004; 231:52-7.
  8. Moskaluk CA, et al. Mod Pathol. 2003; 16:913-9.

Last updated: 2016-09-29 13:18:40

CDX-2
Colon adenocarcinoma is highlighted by CDX-2 antibody in a strong nuclear staining reaction.

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Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: colon
  • Isotype: IgG
  • Dilution Range: 1:100-1:500*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

References


  1. Mazziotta RM, et al. Appl Immunohistochem Mol Morphol. 2005; 13:55-60.
  2. Erickson LA, et al. Endocr Pathol. 2004; 15:247-52.
  3. Saqi A, et al. Am J Clin Pathol. 2005; 123:394-404.
  4. Saad RS, et al. Am J Clin Pathol. 2004; 122:421-7.
  5. Kaimaktchiev V, et al. Mod Pathol. 2004; 17:1392-9.
  6. Werling RW, et al. Am J Surg Pathol. 2003; 27:303-10.
  7. Groisman GM, et al. Int J Gynecol Pathol. 2004; 231:52-7.
  8. Moskaluk CA, et al. Mod Pathol. 2003; 16:913-9.

Download an IFU

Select revision:



Ordering Information

For in vitro diagnostic (IVD) use in USA

DescriptionCat. No.
0.1 ml, concentrate 235R-14
0.5 ml, concentrate 235R-15
1 ml, concentrate 235R-16
1 ml, predilute 235R-17
7 ml, predilute 235R-18
25 ml, predilute 235R-10

For in vitro diagnostic (IVD) use in Canada

DescriptionCat. No.
0.1 ml, concentrate 235R-14
0.5 ml, concentrate 235R-15
1 ml, concentrate 235R-16
1 ml, predilute 235R-17
7 ml, predilute 235R-18
25 ml, predilute 235R-10

For in vitro diagnostic (IVD) use in the EU

DescriptionCat. No.
0.1 ml, concentrate 235R-14
0.5 ml, concentrate 235R-15
1 ml, concentrate 235R-16
1 ml, predilute 235R-17
7 ml, predilute 235R-18
25 ml, predilute 235R-10

For research use only (RUO) in Japan

DescriptionCat. No.
0.1 ml, concentrate 235R-14 (RUO)
0.5 ml, concentrate 235R-15 (RUO)
1 ml, concentrate 235R-16 (RUO)
1 ml, predilute 235R-17 (RUO)
7 ml, predilute 235R-18 (RUO)
25 ml, predilute 235R-10 (RUO)

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: colon
  • Isotype: IgG
  • Dilution Range: 1:100-1:500*

Protocols


  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/10-30minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1S/32min @ 37°C

Download an IFU

Select revision:


Keycode Specific IFU

Keycode:
Select prefix.
Please verify your keycode and try again. If problems presist contact Customer Service
Enter keycode.
Please verify your keycode and try again. If problems presist contact Customer Service

Some products may have special labeling requirements in the United States.

Are you located in the U.S.?


*Note: IFUs with the prefix RUO or ASR are only available for download in English.



Click here to learn about keycodes

References


  1. Mazziotta RM, et al. Appl Immunohistochem Mol Morphol. 2005; 13:55-60.
  2. Erickson LA, et al. Endocr Pathol. 2004; 15:247-52.
  3. Saqi A, et al. Am J Clin Pathol. 2005; 123:394-404.
  4. Saad RS, et al. Am J Clin Pathol. 2004; 122:421-7.
  5. Kaimaktchiev V, et al. Mod Pathol. 2004; 17:1392-9.
  6. Werling RW, et al. Am J Surg Pathol. 2003; 27:303-10.
  7. Groisman GM, et al. Int J Gynecol Pathol. 2004; 231:52-7.
  8. Moskaluk CA, et al. Mod Pathol. 2003; 16:913-9.
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