CDX-2 (EPR2764Y) Rabbit Monoclonal Antibody

CDX-2
Colon adenocarcinoma is highlighted by CDX-2 antibody in a strong nuclear staining reaction.

CDX-2 (EPR2764Y) Rabbit Monoclonal Antibody

Specialties: Anatomic Pathology Gastrointestinal (GI) Pathology

Updated: 2017-05-24 08:46:09

CDX-2 is a caudal-related homeobox transcription factor whose expression in the adult is normally present in the gastrointestinal (GI) epithelium.1 It is implicated in the development and maintenance of the intestinal mucosa.2 This protein is expressed immunohistochemically in the nuclei of normal GI epithelium.1 CDX-2 protein expression has been seen in GI carcinomas. Anti-CDX-2 has been useful to establish GI origin of metastatic adenocarcinomas and carcinoids2,3 and is especially useful to distinguish metastatic colorectal adenocarcinoma from lung adenocarcinoma.1,4,5,6,7 However, mucinous carcinomas of the ovary also stain positively with this antibody, which limits the usefulness of this marker in the distinction of metastatic colorectal adenocarcinoma versus mucinous carcinoma of the ovary.8

  1. Mazziotta RM, et al. Appl Immunohistochem Mol Morphol. 2005; 13:55-60.
  2. Erickson LA, et al. Endocr Pathol. 2004; 15:247-52.
  3. Saqi A, et al. Am J Clin Pathol. 2005; 123:394-404.
  4. Saad RS, et al. Am J Clin Pathol. 2004; 122:421-7.
  5. Kaimaktchiev V, et al. Mod Pathol. 2004; 17:1392-9.
  6. Werling RW, et al. Am J Surg Pathol. 2003; 27:303-10.
  7. Groisman GM, et al. Int J Gynecol Pathol. 2004; 231:52-7.
  8. Moskaluk CA, et al. Mod Pathol. 2003; 16:913-9.

Specifications


  • Reactivity: paraffin
  • Visualization: nuclear
  • Control: colon
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

25 mL predilute235R-10
0.1 mL concentrate235R-14
0.5 mL concentrate235R-15
1 mL concentrate235R-16
1 mL predilute235R-17
7 mL predilute235R-18

For in vitro diagnostic (IVD) use in Canada

25 mL predilute235R-10
0.1 mL concentrate235R-14
0.5 mL concentrate235R-15
1 mL concentrate235R-16
1 mL predilute235R-17
7 mL predilute235R-18

For in vitro diagnostic (IVD) use in Europe

25 mL predilute235R-10
0.1 mL concentrate235R-14
0.5 mL concentrate235R-15
1 mL concentrate235R-16
1 mL predilute235R-17
7 mL predilute235R-18

For research use only (RUO) in Japan

25 mL predilute235R-10-RUO
0.1 mL concentrate235R-14-RUO
0.5 mL concentrate235R-15-RUO
1 mL concentrate235R-16-RUO
1 mL predilute235R-17-RUO
7 mL predilute235R-18-RUO

 

To request information on this product in additional countries, please click the button below.

Literature

Request More Information