Mesothelin (EP140) Rabbit Monoclonal Antibody
Specialties: Anatomic Pathology Cytopathology Pulmonary Pathology
Mesothelin is a 40 kDa glycosyl-phosphatudylinositol-anchored glycoprotein cleaved from a 71kDa precursor protein encoded by the human mesothelin gene. Mesothelin is present on the surface of normal mesothelial cells.1 Although the function of mesothelin is unknown, it is overexpressed in a wide variety of cancers including mesothelioma, pancreatic ductal adenocarcinoma, and ovarian carcinoma.1-6 Mesothelin has proven to be a valuable marker for pancreatic ductal adenocarcinoma due to its strong reactivity in tumor tissue and absence in normal pancreas.1, 3-4 Metastatic renal cell carcinoma can present clinical patterns that mimic primary mesothelioma, pancreatic ductal adenocarcinoma, and ovarian carcinoma.2, 4-6 Mesothelin has demonstrated utility in the differential diagnosis between these primary tumors and corresponding metastatic renal cell carcinoma within the context of an antibody panel.4-6
- Hassan R, et al. Mesothelin targeted cancer immunotherapy. Eur J Cancer. 2008; 44:46-53
- Ordóñez NG. Value of mesothelin immunostaining in the diagnosis of mesothelioma. Mod Pathol. 2003; 16:192-7.
- Hassan R, et al. Mesothelin is overexpressed in pancreaticobiliary adenocarcinomas but not in normal pancreas and chronic pancreatitis. Am J clin Pathol. 2005; 124:838-45.
- Gnemmi V, et al. Pancreatic metastases of renal clear cell carcinoma: a clinicopathological study of 11 cases with special emphasis on the usefulness of PAX2 and mesothelin for the distinction from primary ductal adenocarcinoma of the pancreas. Anal Quant Cytopathol Histopathol. 2013; 35:157-62.
- Ordóñez NG. The diagnostic utility of immunohistochemistry in distinguishing between mesothelioma and renal cell carcinoma: a comparative study. Hum Pathol. 2004; 35:697-710.
- Leroy X, et al. Diagnostic value of cytokeratin 7, CD10 and mesothelin in distinguishing ovarian clear cell carcinoma from metastasis of renal clear cell carcinoma. Histopathology. 2007; 51:874-6.
Specifications
- Reactivity: paraffin
- Visualization: membranous
- Control: mesothelioma, ovarian carcinoma
- Dilution Range: 1:25-1:100*
Package Inserts
IFU
- IVD Rev. 2.0 (CMC43931020)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 439R-14 |
| 0.5 mL concentrate | 439R-15 |
| 1 mL concentrate | 439R-16 |
| 1 mL predilute | 439R-17 |
| 7 mL predilute | 439R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 439R-14 |
| 0.5 mL concentrate | 439R-15 |
| 1 mL concentrate | 439R-16 |
| 1 mL predilute | 439R-17 |
| 7 mL predilute | 439R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 439R-14 |
| 0.5 mL concentrate | 439R-15 |
| 1 mL concentrate | 439R-16 |
| 1 mL predilute | 439R-17 |
| 7 mL predilute | 439R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 439R-14-RUO |
| 0.5 mL concentrate | 439R-15-RUO |
| 1 mL concentrate | 439R-16-RUO |
| 1 mL predilute | 439R-17-RUO |
| 7 mL predilute | 439R-18-RUO |
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