CEA (CEA31) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology
Detection of CEA by immunohistochemistry (IHC) with CEA (CEA31) Mouse Monoclonal Antibody may be used to aid in the diagnosis of colon and lung adenocarcinomas.
CEA (carcinoembryonic antigen) is a glycoprotein that is normally produced in gastrointestinal tissue during fetal development and is involved in cell adhesion.1 CEA is expressed in normal adult tissues including colonic epithelium, some gastric cells, squamous epithelium of the tongue, esophagus and cervix, sweat glands, and prostate epithelium, but not in mesothelium.1 Positive immunohistochemistry with monoclonal CEA antibodies is present in most lung and colorectal carcinomas and some breast carcinomas, but not in mesotheliomas.1-5 Immunohistochemistry for CEA shows a cytoplasmic or membranous pattern of staining.
- Hammarström, S. "The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues." Seminars in cancer biology vol. 9,2 (1999): 67-81.
- Tron, V et al. "Carcinoembryonic antigen and milk-fat globule protein staining of malignant mesothelioma and adenocarcinoma of the lung." Archives of pathology & laboratory medicine vol. 111,3 (1987): 291-3
- Abutaily, A S et al. "Immunohistochemistry in the distinction between malignant mesothelioma and pulmonary adenocarcinoma: a critical evaluation of new antibodies." Journal of clinical pathology vol. 55,9 (2002): 662-8.
- Carella, R et al. "Immunohistochemical panels for differentiating epithelial malignant mesothelioma from lung adenocarcinoma: a study with logistic regression analysis." The American journal of surgical pathology vol. 25,1 (2001): 43-50.
- Lagendijk, J H et al. "Immunohistochemical differentiation between primary adenocarcinomas of the ovary and ovarian metastases of colonic and breast origin. Comparison between a statistical and an intuitive approach." Journal of clinical pathology vol. 52,4 (1999): 283-90.
- Nadji M, Morales AR. Immunoperoxidase, part I: the techniques and its pitfalls. Lab Med 1983;14:767
- Omata M, Liew CT, Ashcavai M, Peters RL. Nonimmunologic binding of horseradish peroxidase to hepatitis B surface antigen. A possible source of error in immunohistochemistry. Am J Clin Pathol. 1980 May; 73(5):626-32. doi: 10.1093/ajcp/73.5.626. PMID: 6155065.
Specifications
- Reactivity: paraffin
- Control: Colon adenocarcinoma (Cytoplasmic); Colon mucosa (Cytoplasmic)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 6.0 (CMC23629060)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 236M-94 |
| 0.5 mL concentrate | 236M-95 |
| 1.0 mL concentrate | 236M-96 |
| 1.0 mL predilute ready-to-use | 236M-97 |
| 7.0 mL predilute ready-to-use | 236M-98 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 236M-94 |
| 0.5 mL concentrate | 236M-95 |
| 1.0 mL concentrate | 236M-96 |
| 1.0 mL predilute ready-to-use | 236M-97 |
| 7.0 mL predilute ready-to-use | 236M-98 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 236M-94 |
| 0.5 mL concentrate | 236M-95 |
| 1.0 mL concentrate | 236M-96 |
| 1.0 mL predilute ready-to-use | 236M-97 |
| 7.0 mL predilute ready-to-use | 236M-98 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 236M-94-RUO |
| 0.5 mL concentrate (RUO) | 236M-95-RUO |
| 1.0 mL concentrate (RUO) | 236M-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 236M-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 236M-98-RUO |
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