Cytokeratin 5 & 6 (D5 & 16B4) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology
Twenty identified cytokeratins make up a complex family of intermediate filaments.1 Cytokeratin 5 (58kDa) & cytokeratin 6 (56kDa) are type II high molecular weight keratins that are expressed in a broad range of normal tissues including breast, prostate, mesothelium, skin and esophagus.1-3 Anti-Cytokeratin 5 & 6 is a useful immunohistochemical marker in the identification of mesothelioma and lung squamous cell carcinoma.1
- Ordóñez NG1. Value of cytokeratin 5/6 immunostaining in distinguishing epithelial mesothelioma of the pleura from lung adenocarcinoma. Am J Surg Pathol. 1998; 22:1215-1221.
- Takahashi K, et al. Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms. J Biol Chem. 1995; 270:18581-92.
- Lersch R, et al. Isolation, sequence, and expression of a human keratin K5 gene: transcriptional regulation of keratins and insights into pairwise control. Mol Cell Biol. 1989; 9:3685-97.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic
- Control: mesothelioma
- Dilution Range: 1:50-1:200*
Package Inserts
IFU
- IVD Rev. 6.0 (CMC35621060)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25 mL predilute | 356M-10 |
| 0.1 mL concentrate | 356M-14 |
| 0.5 mL concentrate | 356M-15 |
| 1 mL concentrate | 356M-16 |
| 1 mL predilute | 356M-17 |
| 7 mL predilute | 356M-18 |
For in vitro diagnostic (IVD) use in Canada
| 25 mL predilute | 356M-10 |
| 0.1 mL concentrate | 356M-14 |
| 0.5 mL concentrate | 356M-15 |
| 1 mL concentrate | 356M-16 |
| 1 mL predilute | 356M-17 |
| 7 mL predilute | 356M-18 |
For in vitro diagnostic (IVD) use in Europe
| 25 mL predilute | 356M-10 |
| 0.1 mL concentrate | 356M-14 |
| 0.5 mL concentrate | 356M-15 |
| 1 mL concentrate | 356M-16 |
| 1 mL predilute | 356M-17 |
| 7 mL predilute | 356M-18 |
For research use only (RUO) in Japan
| 25 mL predilute | 356M-10-RUO |
| 0.1 mL concentrate | 356M-14-RUO |
| 0.5 mL concentrate | 356M-15-RUO |
| 1 mL concentrate | 356M-16-RUO |
| 1 mL predilute | 356M-17-RUO |
| 7 mL predilute | 356M-18-RUO |
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