MUC4 (8G7) Mouse Monoclonal Antibody
Specialties: Soft Tissue Pathology
MUC4 (mucin 4) is a large membrane-anchored glycoprotein of the mucin family that is expressed by epithelial cells in various normal tissues including lung, bronchus, stomach, colon, and cervix.1 MUC4 is generally not detected in normal pancreas, but is expressed in the vast majority of pancreatic neoplasms, such as pancreatic ductal adenocarcinoma.2 Additionally, expression in various carcinomas has been reported, including gastric adenocarcinoma, colon adenocarcinoma, and lung adenocarcinoma.3
- Moniaux N, et al. Generation and characterization of anti-MUC4 monoclonal antibodies reactive with normal and cancer cells in humans. J Histochem Cytochem. 2004; 52:253-61.
- Moniaux N, et al. Multiple roles of mucins in pancreatic cancer, a lethal and challenging malignancy. Br J Cancer. 2004;91:1633-8.
- Llinares K, et al. Diagnostic value of MUC4 immunostaining in distinguishing epithelial mesothelioma and lung adenocarcinoma. Mod Pathol. 2004;17:150-7.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic
- Control: pancreatic ductal adenocarcinoma, colon, colorectal adenocarcinoma
- Dilution Range: 1:10-1:50*
Package Inserts
IFU
- IVD Rev. 3.0 (CMC40621030)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 406M-14 |
| 0.5 mL concentrate | 406M-15 |
| 1 mL concentrate | 406M-16 |
| 1 mL predilute | 406M-17 |
| 7 mL predilute | 406M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 406M-14 |
| 0.5 mL concentrate | 406M-15 |
| 1 mL concentrate | 406M-16 |
| 1 mL predilute | 406M-17 |
| 7 mL predilute | 406M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 406M-14 |
| 0.5 mL concentrate | 406M-15 |
| 1 mL concentrate | 406M-16 |
| 1 mL predilute | 406M-17 |
| 7 mL predilute | 406M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 406M-14-RUO |
| 0.5 mL concentrate | 406M-15-RUO |
| 1 mL concentrate | 406M-16-RUO |
| 1 mL predilute | 406M-17-RUO |
| 7 mL predilute | 406M-18-RUO |
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