Cytokeratin 17 (EP98) on cervical intraepithelial neoplasia III.
Cytokeratin 17 (EP98) Rabbit Monoclonal Antibody
Specialties: Anatomic Pathology
Updated: 2017-05-24 08:46:09
Cytokeratin 17 is 46 kD intermediate filament found in simple epithelia and is a marker for cervical reserve (stem) cells.1,2 CK17 can be useful in the identification of uterine cervical squamous lesions including atypical immature metaplasia, cervical intraepithelial neoplasia, and cervical squamous carcinoma.1-3 CK17 also assists in the differentiation of oral squamous cell carcinoma.4
- Regauer S, et al. CK17 and p16 expression patterns distinguish (atypical) immature squamous metaplasia from high-grade cervical intraepithelial neoplasia (CIN III). Histopathology. 2007; 50:629-35.
- Martens JE, et al. Cytokeratin 17 and p63 are markers of the HPV target cell, the cervical stem cell. Anticancer Res. 2004; 24:771-5.
- Escobar-Hoyos LF, et al. Keratin 17 in premalignant and malignant squamous lesions of the cervix: proteomic discovery and immunohistochemical validation as a diagnostic and prognostic biomarker. Mod Pathol. 2014; 27:621-30.
- Kitamura R. et al. Association of cytokeratin 17 expression with differentiation in oral squamous cell carcinoma. J Cancer Res Clin Oncol. 2012; 138:1299-1310.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic
- Control: cervix immature metaplasia, breast
- Dilution Range: 1:50-1:200*
Package Inserts
IFU
- IVD Rev. 2.0 (CMC31731020)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 317R-14 |
| 0.5 mL concentrate | 317R-15 |
| 1 mL concentrate | 317R-16 |
| 1 mL predilute | 317R-17 |
| 7 mL predilute | 317R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 317R-14 |
| 0.5 mL concentrate | 317R-15 |
| 1 mL concentrate | 317R-16 |
| 1 mL predilute | 317R-17 |
| 7 mL predilute | 317R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 317R-14 |
| 0.5 mL concentrate | 317R-15 |
| 1 mL concentrate | 317R-16 |
| 1 mL predilute | 317R-17 |
| 7 mL predilute | 317R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 317R-14-RUO |
| 0.5 mL concentrate | 317R-15-RUO |
| 1 mL concentrate | 317R-16-RUO |
| 1 mL predilute | 317R-17-RUO |
| 7 mL predilute | 317R-18-RUO |
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