CDX-2 (EPR2764Y) Rabbit Monoclonal Primary Antibody
Specialties: Anatomic Pathology Gastrointestinal (GI) Pathology
Detection of CDX-2 with immunohistochemistry (IHC) with CDX-2 (EPR2764Y) Rabbit Monoclonal Primary Antibody may be used to aid in the diagnosis of colorectal carcinomas.
CDX-2, or caudal-related homeobox gene 2, is a transcription factor that is a major regulator of intestine-specific genes involved in intestinal cell proliferation and differentiation.1 CDX-2 is expressed normally in the upper and lower gastrointestinal tract epithelium, including the stomach, small intestine, colon, and pancreas.2 CDX-2 is also expressed variably in upper and lower gastrointestinal tract carcinomas including most colorectal carcinomas.1-4 CDX-2 immunohistochemistry shows a nuclear pattern of staining.
- Kaimaktchiev, Vassil et al. "The homeobox intestinal differentiation factor CDX2 is selectively expressed in gastrointestinal adenocarcinomas." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc vol. 17,11 (2004): 1392-9.
- Moskaluk, Christopher A et al. "Cdx2 protein expression in normal and malignant human tissues: an immunohistochemical survey using tissue microarrays." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc vol. 16,9 (2003): 913-9.
- Werling, Robert W et al. "CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: an immunohistochemical survey of 476 primary and metastatic carcinomas." The American journal of surgical pathology vol. 27,3 (2003): 303-10.
- Saad, Reda S et al. "Usefulness of Cdx2 in separating mucinous bronchioloalveolar adenocarcinoma of the lung from metastatic mucinous colorectal adenocarcinoma." American journal of clinical pathology vol. 122,3 (2004): 421-7.
- Nadji M, Morales AR. "Immunoperoxidase, part I: the techniques and its pitfalls." Lab Med 1983;14:767.
- Omata M, Liew CT, Ashcavai M, Peters RL. Nonimmunologic binding of horseradish peroxidase to hepatitis B surface antigen. A possible source of error in immunohistochemistry. Am J Clin Pathol. 1980 May; 73(5):626-32. doi: 10.1093/ajcp/73.5.626. PMID: 6155065.
Specifications
- Reactivity: paraffin
- Control: Colon (Nuclear)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 8.0 (CMC23531080)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 235R-10 |
| 0.1 mL concentrate | 235R-14 |
| 0.5 mL concentrate | 235R-15 |
| 1.0 mL concentrate | 235R-16 |
| 1.0 mL predilute ready-to-use | 235R-17 |
| 7.0 mL predilute ready-to-use | 235R-18 |
For in vitro diagnostic (IVD) use in Canada
| 25.0 mL predilute ready-to-use | 235R-10 |
| 0.1 mL concentrate | 235R-14 |
| 0.5 mL concentrate | 235R-15 |
| 1.0 mL concentrate | 235R-16 |
| 1.0 mL predilute ready-to-use | 235R-17 |
| 7.0 mL predilute ready-to-use | 235R-18 |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 235R-10 |
| 0.1 mL concentrate | 235R-14 |
| 0.5 mL concentrate | 235R-15 |
| 1.0 mL concentrate | 235R-16 |
| 1.0 mL predilute ready-to-use | 235R-17 |
| 7.0 mL predilute ready-to-use | 235R-18 |
For research use only (RUO) in Japan
| 25.0 mL predilute ready-to-use (RUO) | 235R-10-RUO |
| 0.1 mL concentrate (RUO) | 235R-14-RUO |
| 0.5 mL concentrate (RUO) | 235R-15-RUO |
| 1.0 mL concentrate (RUO) | 235R-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 235R-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 235R-18-RUO |
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