Colon adenocarcinoma is highlighted by CDX-2 antibody in a strong nuclear staining reaction.
CDX-2 (EPR2764Y) Rabbit Monoclonal Primary Antibody
Specialties: Anatomic Pathology Gastrointestinal (GI) Pathology
Updated: 2022-06-30 14:54:22
CDX-2 is a caudal-related homeobox transcription factor that plays a role in the development and maintenance of intestinal mucosa. This protein is expressed in normal and neoplastic gastrointestinal epithelium, including colorectal adenocarcinoma. It is useful for identifying gastrointestinal origin of benign and malignant lesions.1-7
- Mazziotta, Robert M et al. "CDX2 immunostaining as a gastrointestinal marker: expression in lung carcinomas is a potential pitfall." Applied immunohistochemistry & molecular morphology : AIMM vol. 13,1 (2005): 55-60.
- Erickson, Lori A et al. "Cdx2 as a marker for neuroendocrine tumors of unknown primary sites." Endocrine pathology vol. 15,3 (2004): 247-52.
- Saqi, Anjali et al. "Usefulness of CDX2 and TTF-1 in differentiating gastrointestinal from pulmonary carcinoids." American journal of clinical pathology vol. 123,3 (2005): 394-404.
- Saad, Reda S et al. "Usefulness of Cdx2 in separating mucinous bronchioloalveolar adenocarcinoma of the lung from metastatic mucinous colorectal adenocarcinoma." American journal of clinical pathology vol. 122,3 (2004): 421-7.
- Kaimaktchiev, Vassil et al. "The homeobox intestinal differentiation factor CDX2 is selectively expressed in gastrointestinal adenocarcinomas." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc vol. 17,11 (2004): 1392-9.
- Werling, Robert W et al. "CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: an immunohistochemical survey of 476 primary and metastatic carcinomas." The American journal of surgical pathology vol. 27,3 (2003): 303-10.
- Moskaluk, Christopher A et al. "Cdx2 protein expression in normal and malignant human tissues: an immunohistochemical survey using tissue microarrays." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc vol. 16,9 (2003): 913-9.
Specifications
- Reactivity: paraffin
- Control: Colon (Nuclear)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 7.0 (CMC23531070)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 235R-10 |
| 0.1 mL concentrate | 235R-14 |
| 0.5 mL concentrate | 235R-15 |
| 1.0 mL concentrate | 235R-16 |
| 1.0 mL predilute ready-to-use | 235R-17 |
| 7.0 mL predilute ready-to-use | 235R-18 |
For in vitro diagnostic (IVD) use in Canada
| 25.0 mL predilute ready-to-use | 235R-10 |
| 0.1 mL concentrate | 235R-14 |
| 0.5 mL concentrate | 235R-15 |
| 1.0 mL concentrate | 235R-16 |
| 1.0 mL predilute ready-to-use | 235R-17 |
| 7.0 mL predilute ready-to-use | 235R-18 |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 235R-10 |
| 0.1 mL concentrate | 235R-14 |
| 0.5 mL concentrate | 235R-15 |
| 1.0 mL concentrate | 235R-16 |
| 1.0 mL predilute ready-to-use | 235R-17 |
| 7.0 mL predilute ready-to-use | 235R-18 |
For research use only (RUO) in Japan
| 25.0 mL predilute ready-to-use (RUO) | 235R-10-RUO |
| 0.1 mL concentrate (RUO) | 235R-14-RUO |
| 0.5 mL concentrate (RUO) | 235R-15-RUO |
| 1.0 mL concentrate (RUO) | 235R-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 235R-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 235R-18-RUO |
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