Hepatocyte Specific Antigen (Hep Par-1) (OCH1E5) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology Gastrointestinal (GI) Pathology
Detection of hepatocyte specific antigen (Hep Par-1) by immunohistochemistry (IHC) with Hepatocyte Specific Antigen (Hep Par-1) (OCH1E5) Mouse Monoclonal Antibody may be used to aid in the diagnosis of hepatocellular carcinomas.
Hepatocyte specific antigen, or Hep Par-1, is the enzyme carbamoyl phosphate synthetase 1 (CPS1), a key enzyme of the urea cycle, the process that metabolizes excess ammonia into urea, which occurs primarily in the liver. This mitochondrial enzyme is produced in the liver (hepatocytes) and small intestine, without significant expression in other normal tissues.1 Immunohistochemistry for hepatocyte specific antigen (Hep Par-1) is positive in hepatocellular carcinomas.1-4 Immunohistochemistry for hepatocytes specific antigen shows a granular cytoplasmic pattern of staining.
In combination with other antibodies, this product may be used as an aid in diagnosis.
- Lugli, Alessandro et al. Hepatocyte paraffin 1 expression in human normal and neoplastic tis sues: tissue microarray analysis on 3,940 tissue samples. American journal of clinical pathology vol. 122,5 (2004): 721-7.
- Lau, Sean K et al. Comparative immunohistochemical profile of hepatocellular carcinoma, cholangiocarcinoma, and metastatic adenocarcinoma. Human pathology vol. 33,12 (2002): 1175-81.
- Shiran, M S et al. The utility of hepatocyte paraffin 1 antibody in the immunohistological distinction of hepatocellular carcinoma from cholangiocarcinoma and metastatic carcinoma. The Malaysian journal of pathology vol. 28,2 (2006): 87-92.
- Fan, Zhen et al. Hep par 1 antibody stain for the differential diagnosis of hepatocellular carcinoma: 676 tumors tested using tissue microarrays and conventional tissue sections. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc vol. 16,2 (2003): 137-44.
- Nadji M, Morales AR. Immunoperoxidase, part I: the techniques and its pitfalls. Lab Med 1983;14:767
- Omata M, Liew CT, Ashcavai M, Peters RL. Nonimmunologic binding of horseradish peroxidase to hepatitis B surface antigen. A possible source of error in immunohistochemistry. Am J Clin Pathol. 1980 May; 73(5):626-32. doi: 10.1093/ajcp/73.5.626. PMID: 6155065.
Specifications
- Reactivity: paraffin
- Control: Liver (Cytoplasmic)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 7.0 (CMC26429070)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 264M-90 |
| 0.1 mL concentrate | 264M-94 |
| 0.5 mL concentrate | 264M-95 |
| 1.0 mL concentrate | 264M-96 |
| 1.0 mL predilute ready-to-use | 264M-97 |
| 7.0 mL predilute ready-to-use | 264M-98 |
For in vitro diagnostic (IVD) use in Canada
| 25.0 mL predilute ready-to-use | 264M-90 |
| 0.1 mL concentrate | 264M-94 |
| 0.5 mL concentrate | 264M-95 |
| 1.0 mL concentrate | 264M-96 |
| 1.0 mL predilute ready-to-use | 264M-97 |
| 7.0 mL predilute ready-to-use | 264M-98 |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 264M-90 |
| 0.1 mL concentrate | 264M-94 |
| 0.5 mL concentrate | 264M-95 |
| 1.0 mL concentrate | 264M-96 |
| 1.0 mL predilute ready-to-use | 264M-97 |
| 7.0 mL predilute ready-to-use | 264M-98 |
For research use only (RUO) in Japan
| 25.0 mL predilute ready-to-use | 264M-90-RUO |
| 0.1 mL concentrate | 264M-94-RUO |
| 0.5 mL concentrate | 264M-95-RUO |
| 1.0 mL concentrate | 264M-96-RUO |
| 1.0 mL predilute ready-to-use | 264M-97-RUO |
| 7.0 mL predilute ready-to-use | 264M-98-RUO |
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