Cytokeratin 5 (EP1601Y) Rabbit Monoclonal Antibody
Specialties: Anatomic Pathology
Cytokeratin 5 is an intermediate filament protein of 58 kD molecular weight within the cytokeratin family. It is a type II (basic) cytokeratin. Antibodies to this protein identify basal cells of squamous and glandular epithelia, myoepithelia, and mesothelium.1 Anti-cytokeratin 5 has been reported useful in the differential diagnosis of metastatic carcinoma in the pleura versus epithelioid mesothelioma.2 Epithelioid mesotheliomas are strongly positive in almost all cases, but a minority of pulmonary adenocarcinomas will show focal immunoreactivity.2 Almost all squamous cell carcinomas, half of transitional carcinomas, and many undifferentiated large cell carcinomas immunostain with anti-CK 5.3 Anti-CK 5, along with anti-p63, affords a high sensitivity and specificity for squamous differentiation. Myoepithelial cells of the breast,4,5 glandular epithelia, and basal cells of the prostate are labeled with anti-CK 5.6 This antibody, along with anti-CK 14, has found application in identifying basal-like breast carcinoma.5,7
- Dabbs DJ. Diagnostic Immunohistochemistry. 4th Edition. Elsevier Saunders, Philadelphia, PA. 2014 p. 212.
- Ordonez NG. Human Pathology. 2007; 38:1–16.
- Kargi A, et al. Appl Immunohistochem Mol Morphol. 2007; 15:415–420.
- Clarke CL, et al. J Pathol. 2004; 204:147-52.
- Dabbs DJ, et al. Mod Pathol. 2006; 19:1506-11.
- Dabbs DJ. Diagnostic Immunohistochemistry. 4th Edition. Elsevier Saunders, Philadelphia, PA. 2014 p. 212.
- Livasy CA, et al. Hum Pathol. 2007; 38:197-204.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic
- Control: mesothelioma, prostate
- Dilution Range: 1:50-1:200*
Package Inserts
IFU
- IVD Rev. 5.0 (CMC30531050)
Have a different keycode?
Click Here
Learn how to obtain your SDS
Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 305R-14 |
| 0.5 mL concentrate | 305R-15 |
| 1 mL concentrate | 305R-16 |
| 1 mL predilute | 305R-17 |
| 7 mL predilute | 305R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 305R-14 |
| 0.5 mL concentrate | 305R-15 |
| 1 mL concentrate | 305R-16 |
| 1 mL predilute | 305R-17 |
| 7 mL predilute | 305R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 305R-14 |
| 0.5 mL concentrate | 305R-15 |
| 1 mL concentrate | 305R-16 |
| 1 mL predilute | 305R-17 |
| 7 mL predilute | 305R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 305R-14-RUO |
| 0.5 mL concentrate | 305R-15-RUO |
| 1 mL concentrate | 305R-16-RUO |
| 1 mL predilute | 305R-17-RUO |
| 7 mL predilute | 305R-18-RUO |
To request information on this product in additional countries, please click the button below.