CD23 (SP23) Rabbit Monoclonal Antibody
Specialties: Hematopathology
CD23 antigen is a 45-60 kDa membrane glycoprotein identified as a low affinity receptor for IgE production as well as a receptor for lymphocyte growth factor. CD23 is found in some mature B-cell lymphomas and in Reed-Sternberg cells in Hodgkin disease.1 Follicular dendritic cells and some activated B-cells within germinal centers express CD23 in high density and mantle zone B-cells are stained weakly.2 The majority of chronic lymphocytic leukemias/small lymphocytic lymphomas are CD23 positive, whereas mantle cell lymphomas are generally negative, so this marker is useful when applied with other markers to separate the small cell lymphomas.2 Precursor B and T lymphomas, myeloid neoplasms, and mature T-cell lymphomas are CD23 negative and other small cell lymphomas are occasionally positive.3 CD23 is also positive on activated mature B-cells expressing IgM or IgD, monocytes/macrophages, follicular dendritic cells, T-cell subsets, eosinophils, Langerhans cells and small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL).
- Rowlands DC, et al. Immunohistochemical determination of CD23 expression in Hodgkin’s disease using paraffin sections. J Pathol. 1990; 160:239-43.
- DiRaimondo F, et al. The clinical and diagnostic relevance of CD23 expression in the chronic lymphoproliferative disease. Cancer. 2002; 94:1721-30.
- Raghoebier S, et al. Essential differences in oncogene involvement between primary nodal and extranodal large cell lymphoma. Blood. 1991; 78:2680-5.
Specifications
- Reactivity: paraffin
- Control: Tonsil, Lymph Node (Membranous); Chronic lymphocytic leukemia/Small lymphocytic lymphoma (Membranous)
- Dilution Range: 1:100-1:500*
Package Inserts
IFU
- IVD Rev. 3.0 (CMC12331030)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 123R-14 |
| 0.5 mL concentrate | 123R-15 |
| 1.0 mL concentrate | 123R-16 |
| 1.0 mL predilute ready-to-use | 123R-17 |
| 7.0 mL predilute ready-to-use | 123R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 123R-14 |
| 0.5 mL concentrate | 123R-15 |
| 1.0 mL concentrate | 123R-16 |
| 1.0 mL predilute ready-to-use | 123R-17 |
| 7.0 mL predilute ready-to-use | 123R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 123R-14 |
| 0.5 mL concentrate | 123R-15 |
| 1.0 mL concentrate | 123R-16 |
| 1.0 mL predilute ready-to-use | 123R-17 |
| 7.0 mL predilute ready-to-use | 123R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 123R-14-RUO |
| 0.5 mL concentrate (RUO) | 123R-15-RUO |
| 1.0 mL concentrate (RUO) | 123R-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 123R-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 123R-18-RUO |
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