CD23 (1B12) Mouse Monoclonal Antibody
Specialties: Hematopathology
CD23 antigen is a 45-60 kDa membrane glycoprotein identified as a low affinity receptor for IgE production as well as a receptor for lymphocyte growth factor.1 CD23 is found in some mature B-cell lymphomas and in Reed-Sternberg cells in Hodgkin disease.2 Follicular dendritic cells and some activated B-cells within germinal centers express CD23 in high density and mantle zone B-cells are stained.3 The majority of chronic lymphocytic leukemias/small lymphocytic lymphomas are anti-CD23 positive, whereas mantle cell lymphomas are generally negative, so this marker is useful when applied with other markers to separate the small cell lymphomas.1,3 Precursor B and T lymphomas, myeloid neoplasms, and mature T-cell lymphomas are CD23 negative and other small cell lymphomas are occasionally positive.4 Anti-CD23 is expressed in activated mature B-cells expressing IgM or IgD, monocytes/macrophages, follicular dendritic cells, T-cell subsets, eosinophils, Langerhans cells and small lymphocytic lymphoma/chronic lymphocytic leukemia.1-4
- Fournler S, et al. CD23 antigen regulation and signaling in chronic lympotic leukemia. J Clin. Invest. 1992; 89:1312-21.
- Rowlands DC, et al. Immunohistochemical determination of CD23 expression in Hodgkin’s disease using paraffin sections. J Pathol. 1990; 160:239-43.
- DiRaimondo F, et al. The clinical and diagnostic relevance of CD23 expression in the chronic lymphoproliferative disease. Cancer. 2002; 94:1721-30.
- Raghoebier S, et al. Essential differences in oncogene involvement between primary nodal and extranodal large cell lymphoma. Blood. 1991; 78:2680-5.
Specifications
- Reactivity: paraffin
- Visualization: membranous
- Control: tonsil
- Dilution Range: 1:10-1:50*
Package Inserts
IFU
- IVD Rev. 4.0 (CMC12321040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 123M-14 |
| 0.5 mL concentrate | 123M-15 |
| 1 mL concentrate | 123M-16 |
| 1 mL predilute | 123M-17 |
| 7 mL predilute | 123M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 123M-14 |
| 0.5 mL concentrate | 123M-15 |
| 1 mL concentrate | 123M-16 |
| 1 mL predilute | 123M-17 |
| 7 mL predilute | 123M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 123M-14 |
| 0.5 mL concentrate | 123M-15 |
| 1 mL concentrate | 123M-16 |
| 1 mL predilute | 123M-17 |
| 7 mL predilute | 123M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 123M-14-RUO |
| 0.5 mL concentrate | 123M-15-RUO |
| 1 mL concentrate | 123M-16-RUO |
| 1 mL predilute | 123M-17-RUO |
| 7 mL predilute | 123M-18-RUO |
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