Germinal center and interfollicular B-cells are highlighted by rabbit monoclonal anti-CD20 in a membranous pattern.
CD20 (SP32) Rabbit Monoclonal Antibody
Specialties: Hematopathology
Updated: 2017-05-24 08:46:09
CD20 is a transmembrane protein in late B-cell precursors and mature B-cells that plays a role in regulating proliferation and differentiation. CD20 expression is lost at the plasma cell stage of differentiation.1 Anti-CD20 (pan B-cell)2 has rarely been detected in T-cell malignancies, and is a dependable marker of B-cell lymphomas3 such as DLBCL.4 CD20 expression is present in some thymomas.
- Tedder T, et al. CD20: a regulator of cell-cycle progression of B lymphocytes. Immunol Today. 1994; 15:450-4.
- Mason DY, et al. Antibody L26 recognizes an intracellular epitope on the B-cell-associated CD20 antigen. Am J Pathol. 1990; 136:1215-22.
- Norton AJ, et al. Monoclonal antibody L26: an antibody that is reactive with normal and neoplastic B lymphocytes in routinely fixed and paraffin wax embedded tissues. J Clin Pathol. 1987; 40:1405-12.
- Suzuki Y, et al. Association of CD20 levels with clinicopathological parameters and its prognostic significance for patients with DLBCL. Ann Hematol. 2012; 91:997-1005.
Specifications
- Reactivity: paraffin
- Visualization: membranous
- Control: tonsil
- Dilution Range: 1:100-1:500*
Package Inserts
IFU
- IVD Rev. 3.0 (CMC12031030)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 120R-14 |
| 0.5 mL concentrate | 120R-15 |
| 1 mL concentrate | 120R-16 |
| 1 mL predilute | 120R-17 |
| 7 mL predilute | 120R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 120R-14 |
| 0.5 mL concentrate | 120R-15 |
| 1 mL concentrate | 120R-16 |
| 1 mL predilute | 120R-17 |
| 7 mL predilute | 120R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 120R-14 |
| 0.5 mL concentrate | 120R-15 |
| 1 mL concentrate | 120R-16 |
| 1 mL predilute | 120R-17 |
| 7 mL predilute | 120R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 120R-14-RUO |
| 0.5 mL concentrate | 120R-15-RUO |
| 1 mL concentrate | 120R-16-RUO |
| 1 mL predilute | 120R-17-RUO |
| 7 mL predilute | 120R-18-RUO |
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