CD45 (LCA) (2B11 & PD7/26) Mouse Monoclonal Antibody
Specialties: Hematopathology
Detection of CD45 by immunohistochemistry (IHC) with CD45 (LCA) (2B11 & PD7/26) Mouse Monoclonal Antibody may be used to aid in the diagnosis of non-Hodgkin lymphomas and nodular lymphocyte predominant Hodgkin lymphomas (NLPHLs).
CD45, or leukocyte common antigen (LCA), is a 200-kD glycoprotein that functions as an essential regulator of T- and B-cell antigen receptor signaling. CD45 is expressed on the surface of most white blood cells, or leukocytes.1 CD45 is expressed in non-Hodgkin lymphomas, including T-cell and B-cell lymphomas, as well as in nodular lymphocyte predominant Hodgkin lymphomas (NLPHLs).1-4 Immunohistochemistry for CD45 shows a membranous pattern of staining.
- Park, S H et al."A monoclonal antibody to human leukocyte common antigen, SHL-1, and its use for formalin-fixed, paraffin-embedded tissues."Â Pathology, research and practice vol. 187,1 (1991): 96-102.
- Strauchen, J A. "Leucocyte common antigen in the differential diagnosis of Hodgkin's disease." Hematological oncology vol. 7,2 (1989): 149-53.
- Kurtin, P J, and G S Pinkus. "Leukocyte common antigen--a diagnostic discriminant between hematopoietic and nonhematopoietic neoplasms in paraffin sections using monoclonal antibodies: correlation with immunologic studies and ultrastructural localization." Human pathology vol. 16,4 (1985): 353-65.
- Amini, R M et al. "Patients suffering from both Hodgkin's disease and non-Hodgkin's lymphoma: a clinico-pathological and immuno-histochemical population-based study of 32 patients." International journal of cancer vol. 71,4 (1997): 510-6.
- Nadji M, Morales AR. Immunoperoxidase, part I: the techniques and its pitfalls. Lab Med 1983;14:767
- Omata M, Liew CT, Ashcavai M, Peters RL. Nonimmunologic binding of horseradish peroxidase to hepatitis B surface antigen. A possible source of error in immunohistochemistry. Am J Clin Pathol. 1980 May; 73(5):626-32. doi: 10.1093/ ajcp/73.5.626. PMID: 6155065.
Specifications
- Reactivity: paraffin
- Control: Tonsil, Lymph Node (Membranous); Lymphoma (Membranous)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 7.0 (CMC14529070)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 145M-90 |
| 0.1 mL concentrate | 145M-94 |
| 0.5 mL concentrate | 145M-95 |
| 1.0 mL concentrate | 145M-96 |
| 1.0 mL predilute ready-to-use | 145M-97 |
| 7.0 mL predilute ready-to-use | 145M-98 |
For in vitro diagnostic (IVD) use in Canada
| 25.0 mL predilute ready-to-use | 145M-90 |
| 0.1 mL concentrate | 145M-94 |
| 0.5 mL concentrate | 145M-95 |
| 1.0 mL concentrate | 145M-96 |
| 1.0 mL predilute ready-to-use | 145M-97 |
| 7.0 mL predilute ready-to-use | 145M-98 |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 145M-90 |
| 0.1 mL concentrate | 145M-94 |
| 0.5 mL concentrate | 145M-95 |
| 1.0 mL concentrate | 145M-96 |
| 1.0 mL predilute ready-to-use | 145M-97 |
| 7.0 mL predilute ready-to-use | 145M-98 |
For research use only (RUO) in Japan
| 25.0 mL predilute ready-to-use (RUO) | 145M-90-RUO |
| 0.1 mL concentrate (RUO) | 145M-94-RUO |
| 0.5 mL concentrate (RUO) | 145M-95-RUO |
| 1.0 mL concentrate (RUO) | 145M-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 145M-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 145M-98-RUO |
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