BCL6 (GI191E/A8) Mouse Monoclonal Antibody
Specialties: Hematopathology
Detection of BCL6 by immunohistochemistry (IHC) with BCL6 (GI191E/A8) Mouse Monoclonal Antibody may be used to aid in the diagnosis of follicular lymphomas, diffuse large B-cell lymphomas, and Burkitt lymphomas.
BCL6 is a transcription factor that is involved in germinal center B-cell and follicular helper T-cell differentiation.1 BCL6 expression is seen normally in germinal center B-cells and follicular helper T-cells.1,2 BCL6 expression is usually present in follicular lymphoma,3 diffuse large B-cell lymphomas of germinal center cell type,4 and Burkitt lymphomas.5 Immunohistochemistry for BCL6 shows a nuclear pattern of staining.
In combination with other antibodies, this product may be used as an aid in diagnosis.
BCL6 is protected by U.S. patents 6,174,997 and 6,783,94 (Cancer Genetics, Inc.)
- Falini, B et al. Bcl-6 protein expression in normal and neoplastic lymphoid tissues. Annals of oncology : official journal of the European Society for Medical Oncology vol. 8 Suppl 2 (1997): 101-4.
- Dogan, A et al. CD10 and BCL-6 expression in paraffin sections of normal lymphoid tissue and B-cell lymphomas. The American journal of surgical pathology vol. 24,6 (2000): 846-52.
- Goteri, Gaia et al. Comparison of germinal center markers CD10, BCL6 and human germinal center-associated lymphoma (HGAL) in follicular lymphomas. Diagnostic pathology vol. 6 97. 11 Oct. 2011
- Bajwa, Akhter Ali et al. Immunohistochemical Expression of CD10, BCL6 and MUM1 in Differentiating Diffuse Large B Cell Lymphoma Subtypes. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP vol. 27,10 (2017): 621-624.
- Liu, Yifei et al. combination of LMO2 negative and CD38 positive is useful for the diagnosis of Burkitt lymphoma. Diagnostic pathology vol. 14,1 100. 4 Sep. 2019
- Nadji M, Morales AR. Immunoperoxidase, part I: the techniques and its pitfalls. Lab Med 1983;14:767
- Omata M, Liew CT, Ashcavai M, Peters RL. Nonimmunologic binding of horseradish perox idase to hepatitis B surface antigen. A possible source of error in immunohistochemistry. Am J Clin Pathol. 1980 May; 73(5):626-32. doi: 10.1093/ajcp/73.5.626. PMID: 6155065.
Specifications
- Reactivity: paraffin
- Control: Tonsil (Nuclear)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 9.0 (CMC22729090)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 227M-90 |
| 0.1 mL concentrate | 227M-94 |
| 0.5 mL concentrate | 227M-95 |
| 1.0 mL concentrate | 227M-96 |
| 1.0 mL predilute ready-to-use | 227M-97 |
| 7.0 mL predilute ready-to-use | 227M-98 |
For in vitro diagnostic (IVD) use in Canada
| 25.0 mL predilute ready-to-use | 227M-90 |
| 0.1 mL concentrate | 227M-94 |
| 0.5 mL concentrate | 227M-95 |
| 1.0 mL concentrate | 227M-96 |
| 1.0 mL predilute ready-to-use | 227M-97 |
| 7.0 mL predilute ready-to-use | 227M-98 |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 227M-90 |
| 0.1 mL concentrate | 227M-94 |
| 0.5 mL concentrate | 227M-95 |
| 1.0 mL concentrate | 227M-96 |
| 1.0 mL predilute ready-to-use | 227M-97 |
| 7.0 mL predilute ready-to-use | 227M-98 |
For research use only (RUO) in Japan
| 25.0 mL predilute ready-to-use (RUO) | 227M-90-RUO |
| 0.1 mL concentrate (RUO) | 227M-94-RUO |
| 1.0 mL concentrate (RUO) | 227M-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 227M-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 227M-98-RUO |
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