BCL6 (GI191E/A8) Mouse Monoclonal Antibody
Specialties: Hematopathology
BCL6 is a transcriptional regulator gene which codes for a 706-amino-acid nuclear zinc finger protein.1 In normal tissue, anti-BCL6 antibody shows strong nuclear staining in a subset of B-lymphocytes, mostly located in germinal centers (GC).2 BCL6 expression is usually present in follicular lymphomas,3 diffuse large B-cell lymphomas, and Burkitt lymphomas.4
BCL6 is protected by U.S. patents 6,174,997 and 6,783,94 (Cancer Genetics, Inc.)
- Falini, B et al. "Bcl-6 protein expression in normal and neoplastic lymphoid tissues." Annals of oncology : official journal of the European Society for Medical Oncology vol. 8 Suppl 2 (1997): 101-4.
- Aukema, Sietse M et al. "Double-hit B-cell lymphomas." Blood vol. 117,8 (2011): 2319-31.
- Dogan, A et al. "CD10 and BCL-6 expression in paraffin sections of normal lymphoid tissue and B-cell lymphomas." The American journal of surgical pathology vol. 24,6 (2000): 846-52.
- Carbone, Antonino et al. "B-cell lymphomas with features intermediate between distinct pathologic entities. From pathogenesis to pathology." Human pathology vol. 41,5 (2010): 621-31.
Specifications
- Reactivity: paraffin
- Control: Tonsil (Nuclear)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 8.0 (CMC22729080)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 227M-90 |
| 0.1 mL concentrate | 227M-94 |
| 0.5 mL concentrate | 227M-95 |
| 1.0 mL concentrate | 227M-96 |
| 1.0 mL predilute ready-to-use | 227M-97 |
| 7.0 mL predilute ready-to-use | 227M-98 |
For in vitro diagnostic (IVD) use in Canada
| 25.0 mL predilute ready-to-use | 227M-90 |
| 0.1 mL concentrate | 227M-94 |
| 0.5 mL concentrate | 227M-95 |
| 1.0 mL concentrate | 227M-96 |
| 1.0 mL predilute ready-to-use | 227M-97 |
| 7.0 mL predilute ready-to-use | 227M-98 |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 227M-90 |
| 0.1 mL concentrate | 227M-94 |
| 0.5 mL concentrate | 227M-95 |
| 1.0 mL concentrate | 227M-96 |
| 1.0 mL predilute ready-to-use | 227M-97 |
| 7.0 mL predilute ready-to-use | 227M-98 |
For research use only (RUO) in Japan
| 25.0 mL predilute ready-to-use (RUO) | 227M-90-RUO |
| 0.1 mL concentrate (RUO) | 227M-94-RUO |
| 0.5 mL concentrate (RUO) | 227M-95-RUO |
| 1.0 mL concentrate (RUO) | 227M-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 227M-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 227M-98-RUO |
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