BCL6 (GI191E/A8) Mouse Monoclonal Antibody
Specialties: Hematopathology
Detection of BCL6 by immunohistochemistry (IHC) with BCL6 (GI191E/A8) Mouse Monoclonal Antibody may be used to aid in the diagnosis of follicular lymphomas, diffuse large B-cell lymphomas, and Burkitt lymphomas.
BCL6 is a transcription factor that is involved in germinal center B-cell and follicular helper T-cell differentiation.1 BCL6 expression is seen normally in germinal center B-cells and follicular helper T-cells.1,2 BCL6 expression is usually present in follicular lymphoma,3 diffuse large B-cell lymphomas of germinal center cell type,4 and Burkitt lymphomas.5 Immunohistochemistry for BCL6 shows a nuclear pattern of staining.
BCL6 is protected by U.S. patents 6,174,997 and 6,783,94 (Cancer Genetics, Inc.)
- Falini, B et al. "Bcl-6 protein expression in normal and neoplastic lymphoid tissues." Annals of oncology : official journal of the European Society for Medical Oncology vol. 8 Suppl 2 (1997): 101-4.
- Dogan, A et al. "CD10 and BCL-6 expression in paraffin sections of normal lymphoid tissue and B-cell lymphomas." The American journal of surgical pathology vol. 24,6 (2000): 846-52.
- Goteri, Gaia et al. "Comparison of germinal center markers CD10, BCL6 and human germinal center-associated lymphoma (HGAL) in follicular lymphomas." Diagnostic pathology vol. 6 97. 11 Oct. 2011.
- Bajwa, Akhter Ali et al. "Immunohistochemical Expression of CD10, BCL6 and MUM1 in Differentiating Diffuse Large B Cell Lymphoma Subtypes." Journal of the College of Physicians and Surgeons--Pakistan : JCPSP vol. 27,10 (2017): 621-624.
- Liu, Yifei et al. "A combination of LMO2 negative and CD38 positive is useful for the diagnosis of Burkitt lymphoma." Diagnostic pathology vol. 14,1 100. 4 Sep. 2019
- Nadji M, Morales AR. Immunoperoxidase, part I: the techniques and its pitfalls. Lab Med 1983;14:767
- Omata M, Liew CT, Ashcavai M, Peters RL. Nonimmunologic binding of horseradish peroxidase to hepatitis B surface antigen. A possible source of error in immunohistochemistry. Am J Clin Pathol. 1980 May; 73(5):626-32. doi: 10.1093/ajcp/73.5.626. PMID: 6155065.
Specifications
- Reactivity: paraffin
- Control: Tonsil (Nuclear)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 9.0 (CMC22729090)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 227M-90 |
| 0.1 mL concentrate | 227M-94 |
| 0.5 mL concentrate | 227M-95 |
| 1.0 mL concentrate | 227M-96 |
| 1.0 mL predilute ready-to-use | 227M-97 |
| 7.0 mL predilute ready-to-use | 227M-98 |
For in vitro diagnostic (IVD) use in Canada
| 25.0 mL predilute ready-to-use | 227M-90 |
| 0.1 mL concentrate | 227M-94 |
| 0.5 mL concentrate | 227M-95 |
| 1.0 mL concentrate | 227M-96 |
| 1.0 mL predilute ready-to-use | 227M-97 |
| 7.0 mL predilute ready-to-use | 227M-98 |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 227M-90 |
| 0.1 mL concentrate | 227M-94 |
| 0.5 mL concentrate | 227M-95 |
| 1.0 mL concentrate | 227M-96 |
| 1.0 mL predilute ready-to-use | 227M-97 |
| 7.0 mL predilute ready-to-use | 227M-98 |
For research use only (RUO) in Japan
| 25.0 mL predilute ready-to-use (RUO) | 227M-90-RUO |
| 0.1 mL concentrate (RUO) | 227M-94-RUO |
| 1.0 mL concentrate (RUO) | 227M-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 227M-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 227M-98-RUO |
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