Heat Shock Protein 70 (EP377) Rabbit Monoclonal Primary Antibody
Specialties: Gastrointestinal (GI) Pathology
The Heat Shock Protein 70 family of highly conserved chaperone proteins increase in expression upon exposure to stress factors such as temperature shock, hypoxia, oxidative stress, and pH change.1 This promotes cell survival by repairing misfolded proteins and preventing protein aggregates, among other functions.1 Likewise, tumor cells can use this mechanism to confer a survival advantage as demonstrated in Heat Shock Protein 70 overexpression in hepatocellular carcinoma.1-5
- Murphy ME. The HSP70 family and cancer. Carcinogenesis. 2013; 34(6):1181-8.
- Shin E, et al. The clinicopathological significance of heat shock protein 70 and glutamine synthetase expression in hepatocellular carcinoma. J Hepatobiliary Pancreat Sci. 2011; 18(4):544-50.
- Lagana SM, et al. Utility of an immunohistochemical panel consisting of glypican-3, heat-shock protein-70, and glutamine synthetase in the distinction of low-grade hepatocellular carcinoma from hepatocellular adenoma. Appl Immunohistochem Mol Morphol. 2013; 21(2):170-6.
- Nguyen TB, et al. Combined use of heat-shock protein 70 and glutamine synthetase is useful in the distinction of typical hepatocellular adenoma from atypical hepatocellular neoplasms and well-differentiated hepatocellular carcinoma. Mod Pathol. 2016; 29(3):283-92.
- Di Tommaso L, et al. The application of markers (HSP70, GPC3, and GS) in liver biopsies is useful for detection of hepatocellular carcinoma. J Hepatol. 2009; 50(4):746-54.
Specifications
- Reactivity: paraffin
- Control: Hepatocellular carcinoma (Cytoplasmic, Nuclear)
- Dilution Range: 1:25-1:100 *
Package Inserts
IFU
- IVD Rev. 0.0 (CMC46031000)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 460R-14 |
| 0.5 mL concentrate | 460R-15 |
| 1.0 mL concentrate | 460R-16 |
| 1.0 mL predilute ready-to-use | 460R-17 |
| 7.0 mL predilute ready-to-use | 460R-18 |
This product is not available in Canada
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 460R-14 |
| 0.5 mL concentrate | 460R-15 |
| 1.0 mL concentrate | 460R-16 |
| 1.0 mL predilute ready-to-use | 460R-17 |
| 7.0 mL predilute ready-to-use | 460R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 460R-14-RUO |
| 0.5 mL concentrate (RUO) | 460R-15-RUO |
| 1.0 mL concentrate (RUO) | 460R-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 460R-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 460R-18-RUO |
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