Glutamine Synthetase (GS-6) Mouse Monoclonal Antibody
Specialties: Gastrointestinal (GI) Pathology
Glutamine synthetase (GS) catalyzes the synthesis of glutamine from glutamate and ammonia in the mammalian liver. In normal liver, GS expression is seen in centrilobular (zone 3) hepatocytes, but not in mid-zone (zone 2) or periportal (zone 3) hepatocytes. Glutamine synthetase immunohistochemistry is also positive in neoplasms of hepatocye origin, such as hepatocellular carcinoma (HCC) and hepatocellular adenoma, making it useful for identifying these tumors.1-2
- Di Tommaso, Luca et al. "Diagnostic value of HSP70, glypican 3, and glutamine synthetase in hepatocellular nodules in cirrhosis." Hepatology (Baltimore, Md.) vol. 45,3 (2007): 725-34.
- Nakamoto, Yasunari. "Promising new strategies for hepatocellular carcinoma." Hepatology research : the official journal of the Japan Society of Hepatology vol. 47,4 (2017): 251-265.
Specifications
- Reactivity: paraffin
- Control: Hepatocellular carcinoma (Cytoplasmic)
- Dilution Range: 1:25-1:100 *
Package Inserts
IFU
- IVD Rev. 4.0 (CMC38921040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 389M-14 |
| 0.5 mL concentrate | 389M-15 |
| 1.0 mL concentrate | 389M-16 |
| 1.0 mL predilute ready-to-use | 389M-17 |
| 7.0 mL predilute ready-to-use | 389M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 389M-14 |
| 0.5 mL concentrate | 389M-15 |
| 1.0 mL concentrate | 389M-16 |
| 1.0 mL predilute ready-to-use | 389M-17 |
| 7.0 mL predilute ready-to-use | 389M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 389M-14 |
| 0.5 mL concentrate | 389M-15 |
| 1.0 mL concentrate | 389M-16 |
| 1.0 mL predilute ready-to-use | 389M-17 |
| 7.0 mL predilute ready-to-use | 389M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 389M-14-RUO |
| 0.5 mL concentrate (RUO) | 389M-15-RUO |
| 1.0 mL concentrate (RUO) | 389M-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 389M-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 389M-18-RUO |
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