Glypican-3 antibody displays a diffuse and cytoplasmic staining pattern in the neoplastic cells of hepatocellular carcinoma. Note non-neoplastic hepatocytes are negative for glypican-3.
Glypican-3 (1G12) Mouse Monoclonal Antibody
Specialties: Gastrointestinal (GI) Pathology
Updated: 2017-05-24 08:46:09
Glypican-3 (GPC3) is a membrane-bound heparin sulfate proteoglycan known to participate in cell growth and differentiation.1 GPC3 expression has been observed in the majority of hepatocellular carcinomas (HCC), but is rarely expressed in non-neoplastic hepatic tissue, making it a useful marker for HCC.1-3 Additionally, this marker is expressed in many yolk sac tumors.1,4
- Kandil DH, et al. Glypican-3 a novel diagnostic marker for hepatocellular carcinoma and more. Adv Anat Pathol. 2009; 16:125-9.
- Coston WMP, et al. Distinction of hepatocellular carcinoma from benign hepatic mimickers using Glypican-3 and CD34 immunohistochemistry. Am J Surg Pathol. 2008; 32:433-44.
- Capurro M, et al. Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma. Gastroenterology. 2003; 125:89-97.
- Zynger DL, et al. Glypican 3: a novel marker in testicular germ cell tumors. Am J Surg Pathol. 2006; 30:1570-5.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic
- Control: hepatocellular carcinoma
- Dilution Range: 1:100-1:500*
Package Inserts
IFU
- IVD Rev. 6.0 (CMC26129060)
Have a different keycode?
Click Here
Learn how to obtain your SDS
Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25 mL predilute | 261M-90 |
| 0.1 mL concentrate | 261M-94 |
| 0.5 mL concentrate | 261M-95 |
| 1 mL concentrate | 261M-96 |
| 1 mL predilute | 261M-97 |
| 7 mL predilute | 261M-98 |
For in vitro diagnostic (IVD) use in Canada
| 25 mL predilute | 261M-90 |
| 0.1 mL concentrate | 261M-94 |
| 0.5 mL concentrate | 261M-95 |
| 1 mL concentrate | 261M-96 |
| 1 mL predilute | 261M-97 |
| 7 mL predilute | 261M-98 |
For in vitro diagnostic (IVD) use in Europe
| 25 mL predilute | 261M-90 |
| 0.1 mL concentrate | 261M-94 |
| 0.5 mL concentrate | 261M-95 |
| 1 mL concentrate | 261M-96 |
| 1 mL predilute | 261M-97 |
| 7 mL predilute | 261M-98 |
For research use only (RUO) in Japan
| 25 mL predilute | 261M-90-RUO |
| 0.1 mL concentrate | 261M-94-RUO |
| 0.5 mL concentrate | 261M-95-RUO |
| 1 mL concentrate | 261M-96-RUO |
| 1 mL predilute | 261M-97-RUO |
| 7 mL predilute | 261M-98-RUO |
To request information on this product in additional countries, please click the button below.
