CD123 (6H6) Mouse Monoclonal Antibody
Specialties: Hematopathology
Blastic plasmacytoid dendritic cell neoplasm (BPDCN), previously known as CD4+/CD56+ hematodermic neoplasm or blastic NK-cell lymphoma, is a malignant neoplasm composed of immature hematopoietic precursors of plasmacytoid dendritic cells.1 The most frequent manifestation is a skin lesion, bone marrow involvement, and regional lymphadenopathy.1 Myeloid leukemia cutis (LC), myeloid sarcoma, and large aggressive B cell lymphomas should be differentiated from BPDCN. Recently, it has been reported that these entities can be distinguished by using immunohistochemistry (IHC) in paraffin-embedded tissue sections.2 CD123 is able to distinguish BPDCN from diffuse large B-cell lymphoma, follicular lymphoma, marginal zone lymphoma, hairy cell leukemia, and small lymphocytic lymphoma.
- Facchetti F, et al. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon, France: IARC Press; 2008:145-7.
- Cronin DMP, et al. Immunophenotypic analysis of myeloperoxidase-negative leukemia cutis and blastic plasmacytoid dendritic cell neoplasm. Am J Clin Pathol. 2012; 137:367-76.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic
- Control: blastic plasmacytoid dendritic cell neoplasm
- Dilution Range: 1:25-1:100*
Package Inserts
IFU
- IVD Rev. 2.0 (CMC19821020)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 198M-14 |
| 0.5 mL concentrate | 198M-15 |
| 1 mL concentrate | 198M-16 |
| 1 mL predilute | 198M-17 |
| 7 mL predilute | 198M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 198M-14 |
| 0.5 mL concentrate | 198M-15 |
| 1 mL concentrate | 198M-16 |
| 1 mL predilute | 198M-17 |
| 7 mL predilute | 198M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 198M-14 |
| 0.5 mL concentrate | 198M-15 |
| 1 mL concentrate | 198M-16 |
| 1 mL predilute | 198M-17 |
| 7 mL predilute | 198M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 198M-14-RUO |
| 0.5 mL concentrate | 198M-15-RUO |
| 1 mL concentrate | 198M-16-RUO |
| 1 mL predilute | 198M-17-RUO |
| 7 mL predilute | 198M-18-RUO |
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