CD56 (MRQ-42) Rabbit Monoclonal Antibody
Specialties: Anatomic Pathology
Detection of CD56 by immunohistochemistry (IHC) with CD56 (MRQ-42) Rabbit Monoclonal Antibody may be used to aid in the diagnosis of neuroendocrine neoplasms and natural killer (NK)-cell lymphomas.
CD56, or neural cell adhesion molecule (N-CAM), is a membrane bound glycoprotein belonging to the immunoglobulin gene superfamily.1 CD56 is involved in the regulation of cell-cell adhesion between neurons and cell-matrix adhesion between neurons and muscle.1 It is normally expressed in neuroendocrine cells and natural killer cells. Immunohistochemistry for CD56 is positive in neuroendocrine neoplasms and NK-cell lymphomas.2–5 Immunohistochemistry for CD56 shows a membranous or cytoplasmic pattern of staining.
In combination with other antibodies, this product may be used as an aid in diagnosis.
- Jin, L et al."Expression of neural cell adhesion molecule in normal and neoplastic human neuroendocrine tissues." The American journal of pathology vol. 138,4 (1991): 961-9.
- Ye, Bo et al. "ASH1 is a specific immunohistochemical marker for lung neuroendocrine tumors." Human pathology vol. 48 (2016): 142-7.
- Rooper, Lisa M et al. "NSM1 Demonstrates Superior Performance to the Individual and Combined Use of Synaptophysin, Chromogranin and CD56 for Diagnosing Neuroendocrine Tumors of the Thoracic Cavity." The American journal of surgical pathology vol. 41,11 (2017): 1561-1569.
- Li, Jun-Dong et al. "A clinicopathological aspect of primary small-cell carcinoma of the uterine cervix: a single-centre study of 25 cases." Journal of clinical pathology vol. 64,12 (2011): 1102-7.
- Nong, Lin et al. Zhonghua bing li xue za zhi = Chinese journal of pathology vol. 39,5 (2010): 319-24.
- Nadji M, Morales AR. Immunoperoxidase, part I: the techniques and its pitfalls. Lab Med 1983;14:767
- Omata M, Liew CT, Ashcavai M, Peters RL. Non immunologic binding of horseradish peroxidase to hepatitis B surface antigen. A possible source of error in immunohistochemistry. Am J Clin Pathol. 1980 May; 73(5):626-32. doi: 10.1093/ ajcp/73.5.626. PMID: 6155065.
Specifications
- Reactivity: paraffin
- Control: Neuroblastoma (Cytoplasmic, Membranous)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 5.0 (CMC15639050)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 156R-94 |
| 0.5 mL concentrate | 156R-95 |
| 1.0 mL concentrate | 156R-96 |
| 1.0 mL predilute ready-to-use | 156R-97 |
| 7.0 mL predilute ready-to-use | 156R-98 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 156R-94 |
| 0.5 mL concentrate | 156R-95 |
| 1.0 mL concentrate | 156R-96 |
| 1.0 mL predilute ready-to-use | 156R-97 |
| 7.0 mL predilute ready-to-use | 156R-98 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 156R-94 |
| 0.5 mL concentrate | 156R-95 |
| 1.0 mL concentrate | 156R-96 |
| 1.0 mL predilute ready-to-use | 156R-97 |
| 7.0 mL predilute ready-to-use | 156R-98 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 156R-94-RUO |
| 0.5 mL concentrate (RUO) | 156R-95-RUO |
| 1.0 mL concentrate (RUO) | 156R-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 156R-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 156R-98-RUO |
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