Interfollicular T-lymphocytes are highlighted by CD4 antibody in a cytoplasmic pattern. Note scattered intrafollicular T-cells also express CD4 antigen.
CD4 (SP35) Rabbit Monoclonal Antibody
Specialties: Hematopathology
Updated: 2022-09-15 15:44:10
CD4 is a 55-kD glycoprotein expressed on the surface of T-helper/regulatory T-cells, monocytes, macrophages, and some dendritic cells. The majority of peripheral T-cell lymphomas are derived from the T-helper/regulatory cell subset so that most mature T-cell neoplasms are CD4+. Anti-CD4 is used to identify normal T-cells and to aid in the identification of neoplasms of T-cell origin.1-3
- Jasani, Bharat. "Manual of Diagnostic Antibodies for Immunohistology: Leong AS-Y, Cooper K, Joel F, Leong W-M. (£45.00.) Oxford University Press, 1999. ISBN 1 900151 31 6." Molecular Pathology vol. 53,1 (2000): 53.
- Akiyama, Takashi et al. "CD8+, CD56+ (natural killer-like) T-cell lymphoma involving the small intestine with no evidence of enteropathy: clinicopathology and molecular study of five Japanese patients." Pathology international vol. 58,10 (2008): 626-34.
- Garcia-Herrera, Adriana et al. "Primary cutaneous small/medium CD4+ T-cell lymphomas: a heterogeneous group of tumors with different clinicopathologic features and outcome." Journal of clinical oncology : official journal of the American Society of Clinical Oncology vol. 26,20 (2008): 3364-71.
Specifications
- Reactivity: paraffin
- Control: Tonsil (Cytoplasmic, Membranous); Lymph Node (Cytoplasmic, Membranous)
- Dilution Range: 1:25-1:100 *
Package Inserts
IFU
- IVD Rev. 5.0 (CMC10431050)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 104R-14 |
| 0.5 mL concentrate | 104R-15 |
| 1.0 mL concentrate | 104R-16 |
| 1.0 mL predilute ready-to-use | 104R-17 |
| 7.0 mL predilute ready-to-use | 104R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 104R-14 |
| 0.5 mL concentrate | 104R-15 |
| 1.0 mL concentrate | 104R-16 |
| 1.0 mL predilute ready-to-use | 104R-17 |
| 7.0 mL predilute ready-to-use | 104R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 104R-14 |
| 0.5 mL concentrate | 104R-15 |
| 1.0 mL concentrate | 104R-16 |
| 1.0 mL predilute ready-to-use | 104R-17 |
| 7.0 mL predilute ready-to-use | 104R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 104R-14-RUO |
| 0.5 mL concentrate (RUO) | 104R-15-RUO |
| 1.0 mL concentrate (RUO) | 104R-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 104R-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 104R-18-RUO |
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