TCL1 (MRQ-7) Mouse Monoclonal Antibody
Specialties: Hematopathology
T-cell leukemia/lymphoma protein 1 (TCL1, TCL1A, p14TCL1) is a 14 kDa product of the TCL1 gene that is involved in T-cell prolymphocytic leukemia (T-PLL). TCL1 protein is normally found in the nucleus and cytoplasm of lymphoid lineage cells during early embryogenesis. TCL1 is expressed in differentiated B-cells under both reactive and neoplastic conditions, antigen committed B-cells, and in germinal center B-cells. The Anti-TCL1 immunohistochemical reactivity is reportedly useful identifying B-cell lymphomas including follicular lymphoma and Burkitt lymphoma.1-10
- Narducci MG, et al. Regulation of TCL1 expression in B- and T-cell lymphomas and reactive lymphoid tissues. Cancer Res. 2000; 60:2095-100.
- Roos J, et al. Expression of TCL1 in hematologic disorders. Pathobiology. 2001; 69:59-66.
- Pescarmona E, et al. Expression of TCL1 and CD27 in primary cutaneous B-cell lymphomas. Histopathology. 2006; 49:343-8.
- Rodig SJ, et al. Characteristic expression patterns of TCL1, CD 38, and CD44 identify aggressive lymphomas harboring MYC translocation. Am J Surg Pathol. 2008; 32:113-22.
- Nakayama I, et al. Activation of the TCL1 protein in B cell lymphomas. Pathol Int. 2000; 50:191-9.
- Pekarsky Y, et al. The role of TCL1 in human leukemia. Oncogene. 2001; 20:5638-43.
- Pekarsky Y, et al. TCL1 as a model for lymphomagenesis. Hematol Oncol Clin North Am. 2004; 18:863-79.
- Takizawa J, et al. Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia. Jpn J Cancer Res. 1998; 89:712-8.
- Bichi R, et al. Huamn chronic lymphocytic leukemia modeled in mouse targeted TCL1 expression. Proc Natl Acad Sci USA. 2002; 99:6955-60.
- Herling M, et al. TCL1 shows a regulated expression pattern in chronic lymphocytic leukemia that correlates with molecular subtypes and proliferative state. Leukemia. 2006; 20:280-5.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic, nuclear
- Control: tonsil, B-cell lymphoma
- Dilution Range: 1:100-1:500*
Package Inserts
IFU
- IVD Rev. 4.0 (CMC35721040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 357M-14 |
| 0.5 mL concentrate | 357M-15 |
| 1 mL concentrate | 357M-16 |
| 1 mL predilute | 357M-17 |
| 7 mL predilute | 357M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 357M-14 |
| 0.5 mL concentrate | 357M-15 |
| 1 mL concentrate | 357M-16 |
| 1 mL predilute | 357M-17 |
| 7 mL predilute | 357M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 357M-14 |
| 0.5 mL concentrate | 357M-15 |
| 1 mL concentrate | 357M-16 |
| 1 mL predilute | 357M-17 |
| 7 mL predilute | 357M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 357M-14-RUO |
| 0.5 mL concentrate | 357M-15-RUO |
| 1 mL concentrate | 357M-16-RUO |
| 1 mL predilute | 357M-17-RUO |
| 7 mL predilute | 357M-18-RUO |
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