p27Kip1 (SX53G8) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology
p27Kip1, also known as cyclin-dependent kinase inhibitor 1B (CDNK1B), is a kinase inhibitor that controls cell cycle progression.1-4 p27Kip1 is involved in G1 phase arrest and obstructs cell entry into the S phase by binding to and inhibiting cyclin E-CDK2, effectively slowing or stopping the cell division cycle.1-4 p27Kip1 is broadly expressed in normal tissue but can be dysfunctional in neoplastic tissue and, therefore, not expressed.1-2
- Polyak K, et al. Cell. 1994; 78:59-66.
- Sun C, et al. AM J Cancer Res. 2016; 6:2207-20.
- Sangfelt O, et al. Oncogene. 1999; 18:2798-810.
- Hsieh FF, et al. Blood. 2000; 96:2746-54.
Specifications
- Reactivity: paraffin
- Visualization: nuclear
- Control: tonsil
- Dilution Range: 1:100-1:500*
Package Inserts
IFU
- IVD Rev. 4.0 (CMC42729040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 427M-94 |
| 0.5 mL concentrate | 427M-95 |
| 1 mL concentrate | 427M-96 |
| 1 mL predilute | 427M-97 |
| 7 mL predilute | 427M-98 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 427M-94 |
| 0.5 mL concentrate | 427M-95 |
| 1 mL concentrate | 427M-96 |
| 1 mL predilute | 427M-97 |
| 7 mL predilute | 427M-98 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 427M-94 |
| 0.5 mL concentrate | 427M-95 |
| 1 mL concentrate | 427M-96 |
| 1 mL predilute | 427M-97 |
| 7 mL predilute | 427M-98 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 427M-94-RUO |
| 0.5 mL concentrate | 427M-95-RUO |
| 1 mL concentrate | 427M-96-RUO |
| 1 mL predilute | 427M-97-RUO |
| 7 mL predilute | 427M-98-RUO |
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