Case Study #3
April 2017
A 62 year old HIV-negative male non-smoker and non-drinker has chronic fever, fatigue, and weight loss over a 30 day period. His WBC was 9500 with 81% lymphocytes, his hemoglobin was 12.4 and his LDH was 370. Physical examination shows swelling in the neck and abdomen, and a CT scan shows signs of splenomegaly and central and peripheral lymphadenopathy, with progressively enlarging retroperitoneal lymph nodes. A lymph node biopsy was taken and the histology stains are below.
What is the diagnosis?

H&Ex100

H&Ex200
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CD20x200
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CD3x200
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BCL2x200
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CD5x200
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CD10x200
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CD21x200
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CD23x200
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Cyclin D1x200
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SOX-11x200