CD20 (SP32) Rabbit Monoclonal Antibody

CD20
Germinal center and interfollicular B-cells are highlighted by rabbit monoclonal anti-CD20 in a membranous pattern.

CD20 (SP32) Rabbit Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-24 08:46:09

CD20 is a transmembrane protein in late B-cell precursors and mature B-cells that plays a role in regulating proliferation and differentiation. CD20 expression is lost at the plasma cell stage of differentiation.1 Anti-CD20 (pan B-cell)2 has rarely been detected in T-cell malignancies, and is a dependable marker of B-cell lymphomas3 such as DLBCL.4 CD20 expression is present in some thymomas.

  1. Tedder T, et al. CD20: a regulator of cell-cycle progression of B lymphocytes. Immunol Today. 1994; 15:450-4.
  2. Mason DY, et al. Antibody L26 recognizes an intracellular epitope on the B-cell-associated CD20 antigen. Am J Pathol. 1990; 136:1215-22.
  3. Norton AJ, et al. Monoclonal antibody L26: an antibody that is reactive with normal and neoplastic B lymphocytes in routinely fixed and paraffin wax embedded tissues. J Clin Pathol. 1987; 40:1405-12.
  4. Suzuki Y, et al. Association of CD20 levels with clinicopathological parameters and its prognostic significance for patients with DLBCL. Ann Hematol. 2012; 91:997-1005.

Specifications


  • Reactivity: paraffin
  • Visualization: membranous
  • Control: tonsil
  • Dilution Range: 1:100-1:500*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate120R-14
0.5 mL concentrate120R-15
1 mL concentrate120R-16
1 mL predilute120R-17
7 mL predilute120R-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate120R-14
0.5 mL concentrate120R-15
1 mL concentrate120R-16
1 mL predilute120R-17
7 mL predilute120R-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate120R-14
0.5 mL concentrate120R-15
1 mL concentrate120R-16
1 mL predilute120R-17
7 mL predilute120R-18

For research use only (RUO) in Japan

0.1 mL concentrate120R-14-RUO
0.5 mL concentrate120R-15-RUO
1 mL concentrate120R-16-RUO
1 mL predilute120R-17-RUO
7 mL predilute120R-18-RUO

 

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