Cell Marque Portfolio

CD10 (56C6)

Mouse Monoclonal


CD10, common acute lymphoblastic leukemia antigen, is expressed in early lymphoid progenitors and normal germinal center cells.1 The staining pattern is cytoplasmic. As with BCL6, an antibody against CD10 is used to identify B cells of germinal center origin and their neoplastic counterparts, such as follicular lymphoma. It can be used in combination with other stains such as BCL6, MUM1, FOXP1, GCET, and LMO2 to identify diffuse large B cell lymphoma with germinal center signature.2 This antibody almost always labels precursor B lymphoblastic leukemia/lymphoma and Burkitt lymphoma, but much less frequently labels precursor T lymphoblastic leukemia/lymphoma.2 CD10 is expressed by a subset of T follicular helper cells, although not by normal peripheral T cells. CD10 expression has been found in angioimmunoblastic T cell lymphoma (AITL).2 The expression is highly specific for AITL because other nodal peripheral T cell lymphomas only rarely express this antigen. 2,3 CD10 expression has been reported in a variety of non-hematolymphoid tissues and their neoplastic counterparts; in particular, renal cell carcinoma, endometrial stromal sarcoma, and hepatocellular carcinoma, among other malignant tumors. 4,5 The clone 56C6 shows higher staining intensity in non-hematolymphoid than hematolymphoid neoplasms.

Specialties: Hematopathology

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: kidney, lymph node, tonsil,
  • Isotype: IgG1
  • Dilution Range: 1:10-1:50*

Protocols


  • Cell Marque HiDef
    T-PC/30-60minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/30-60minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1S/32min @ 37°C + AMP

Download an IFU

Select revision:


Keycode Specific IFU

Keycode:
Select prefix.
Please verify your keycode and try again. If problems presist contact Customer Service
Enter keycode.
Please verify your keycode and try again. If problems presist contact Customer Service

Some products may have special labeling requirements in the United States.

Are you located in the U.S.?



*Note: IFUs with the prefix RUO or ASR are only available for download in English.


Click here to learn about keycodes

References


  1. Shipp MA, et al. PNAS USA. 1989; 86:297-301.
  2. Swerdlow S, et al. WHO classification of tumours of hematopoietic and lymphoid tissues. 4th edition. 2008. 220,233,255,265,309.
  3. Attugalle AD, et al. Histopathol. 2007; 50:498-508.
  4. Sangio AR, et al. ADV ANAT Pathol. 2010; 17:377-93.
  5. McCluggage WG, et al. Histopathol. 2001; 39: 273-6.

Literature

Last updated: 2016-09-29 13:18:40

CD10
Germinal center cells demonstrate strong cytoplasmic CD10 protein expression.

Mouse over to zoom, use scroll wheel to zoom in/out

Tap image once to activate zoom lens


Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: kidney, lymph node, tonsil,
  • Isotype: IgG1
  • Dilution Range: 1:10-1:50*

Protocols


  • Cell Marque HiDef
    T-PC/30-60minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/30-60minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1S/32min @ 37°C + AMP

References


  1. Shipp MA, et al. PNAS USA. 1989; 86:297-301.
  2. Swerdlow S, et al. WHO classification of tumours of hematopoietic and lymphoid tissues. 4th edition. 2008. 220,233,255,265,309.
  3. Attugalle AD, et al. Histopathol. 2007; 50:498-508.
  4. Sangio AR, et al. ADV ANAT Pathol. 2010; 17:377-93.
  5. McCluggage WG, et al. Histopathol. 2001; 39: 273-6.

Download an IFU

Select revision:



Ordering Information

For in vitro diagnostic (IVD) use in USA

DescriptionCat. No.
0.1 ml, concentrate 110M-14
0.5 ml, concentrate 110M-15
1 ml, concentrate 110M-16
1 ml, predilute 110M-17
7 ml, predilute 110M-18
25 ml, predilute 110M-10

For in vitro diagnostic (IVD) use in Canada

DescriptionCat. No.
0.1 ml, concentrate 110M-14
0.5 ml, concentrate 110M-15
1 ml, concentrate 110M-16
1 ml, predilute 110M-17
7 ml, predilute 110M-18
25 ml, predilute 110M-10

For in vitro diagnostic (IVD) use in the EU

DescriptionCat. No.
0.1 ml, concentrate 110M-14
0.5 ml, concentrate 110M-15
1 ml, concentrate 110M-16
1 ml, predilute 110M-17
7 ml, predilute 110M-18
25 ml, predilute 110M-10

For research use only (RUO) in Japan

DescriptionCat. No.
0.1 ml, concentrate 110M-14 (RUO)
0.5 ml, concentrate 110M-15 (RUO)
1 ml, concentrate 110M-16 (RUO)
1 ml, predilute 110M-17 (RUO)
7 ml, predilute 110M-18 (RUO)
25 ml, predilute 110M-10 (RUO)

Literature

Specifications


  • Reactivity: paraffin
  • Visualization: cytoplasmic, membranous
  • Control: kidney, lymph node, tonsil,
  • Isotype: IgG1
  • Dilution Range: 1:10-1:50*

Protocols


  • Cell Marque HiDef
    T-PC/30-60minAb/HiDef/Perm Red
  • Cell Marque HiDef
    T-PC/30-60minAb/HiDef/DAB
  • Ventana ultraView
    UV/CC1S/32min @ 37°C + AMP

Download an IFU

Select revision:


Keycode Specific IFU

Keycode:
Select prefix.
Please verify your keycode and try again. If problems presist contact Customer Service
Enter keycode.
Please verify your keycode and try again. If problems presist contact Customer Service

Some products may have special labeling requirements in the United States.

Are you located in the U.S.?


*Note: IFUs with the prefix RUO or ASR are only available for download in English.



Click here to learn about keycodes

References


  1. Shipp MA, et al. PNAS USA. 1989; 86:297-301.
  2. Swerdlow S, et al. WHO classification of tumours of hematopoietic and lymphoid tissues. 4th edition. 2008. 220,233,255,265,309.
  3. Attugalle AD, et al. Histopathol. 2007; 50:498-508.
  4. Sangio AR, et al. ADV ANAT Pathol. 2010; 17:377-93.
  5. McCluggage WG, et al. Histopathol. 2001; 39: 273-6.
Request More Information