CD21 (2G9) Mouse Monoclonal Antibody

CD21
Germinal center follicular dendritic cells are stained with CD21 antibody in a cytoplasmic reaction.

CD21 (2G9) Mouse Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-24 08:46:09

CD21 (also known as complement receptor 2 (CR2), C3d receptor, or EBV receptor) is a 140 kDa membrane protein on B-lymphocytes to which the Epstein-Barr virus (EBV) binds during infection of these cells.1 The antigen is absent on T-lymphocytes, monocytes, and granulocytes.2,3

Anti-CD21 is useful in the identification of follicular dendritic cell matrix found in normal lymph node and tonsillar tissue. This antibody also labels follicular dendritic cell sarcomas.2,4,5 Anti-CD21 is valuable in differentiating follicular lymphoma with marginal zone differentiation from marginal zone lymphoma with follicular involvement. It also plays a role in distinguishing among nodular lymphocyte predominant Hodgkin lymphoma, lymphocyte-rich classic Hodgkin lymphoma, and T-cell/histiocyte-rich B-cell lymphoma in combination with other B-cell and T-cell markers.6 Anti-CD21 is also useful in identifying abnormal follicular dendritic cell pattern in angioimmunoblastic T-cell lymphoma and follicular T-cell lymphoma.7

  1. Cheuk W, et al. Am J Surg Pathol. 2001; 25:721-31.
  2. Pileri SA, et al.Histopathology. 2002; 41:1-29.
  3. Maeda K, et al. J Histochem Cytochem. 2002; 50:1475-1486.
  4. Biddle DA, et al. Mod Pathol. 2002; 15:50-8.
  5. Chan AC, et al. Histopathology. 2001; 38:510-8.
  6. Chang KC, et al. J Pathol. 2003; 201:404-12.
  7. Chuang SS, et al. Int J Hematol. 2010; 91:687-91.

Specifications


  • Reactivity: paraffin
  • Visualization: membranous
  • Control: tonsil
  • Dilution Range: 1:25-1:100*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate121M-14
0.5 mL concentrate121M-15
1 mL concentrate121M-16
1 mL predilute121M-17
7 mL predilute121M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate121M-14
0.5 mL concentrate121M-15
1 mL concentrate121M-16
1 mL predilute121M-17
7 mL predilute121M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate121M-14
0.5 mL concentrate121M-15
1 mL concentrate121M-16
1 mL predilute121M-17
7 mL predilute121M-18

For research use only (RUO) in Japan

0.1 mL concentrate121M-14-RUO
0.5 mL concentrate121M-15-RUO
1 mL concentrate121M-16-RUO
1 mL predilute121M-17-RUO
7 mL predilute121M-18-RUO

 

To request information on this product in additional countries, please click the button below.

Request More Information