CD23 (1B12) Mouse Monoclonal Antibody

CD23
Germinal center follicular dendritic cells show a strong cytoplasmic staining by CD23 antibody. Note the mantle cells demonstrate weak staining.

CD23 (1B12) Mouse Monoclonal Antibody

Specialties: Hematopathology

Updated: 2017-05-24 08:46:09

CD23 antigen is a 45-60 kDa membrane glycoprotein identified as a low affinity receptor for IgE production as well as a receptor for lymphocyte growth factor.1 CD23 is found in some mature B-cell lymphomas and in Reed-Sternberg cells in Hodgkin disease.2 Follicular dendritic cells and some activated B-cells within germinal centers express CD23 in high density and mantle zone B-cells are stained.3 The majority of chronic lymphocytic leukemias/small lymphocytic lymphomas are anti-CD23 positive, whereas mantle cell lymphomas are generally negative, so this marker is useful when applied with other markers to separate the small cell lymphomas.1,3 Precursor B and T lymphomas, myeloid neoplasms, and mature T-cell lymphomas are CD23 negative and other small cell lymphomas are occasionally positive.4  Anti-CD23 is expressed in activated mature B-cells expressing IgM or IgD, monocytes/macrophages, follicular dendritic cells, T-cell subsets, eosinophils, Langerhans cells and small lymphocytic lymphoma/chronic lymphocytic leukemia.1-4

  1. Fournler S, et al. CD23 antigen regulation and signaling in chronic lympotic leukemia. J Clin. Invest. 1992; 89:1312-21.
  2. Rowlands DC, et al. Immunohistochemical determination of CD23 expression in Hodgkin’s disease using paraffin sections. J Pathol. 1990; 160:239-43.
  3. DiRaimondo F, et al. The clinical and diagnostic relevance of CD23 expression in the chronic lymphoproliferative disease. Cancer. 2002; 94:1721-30.
  4. Raghoebier S, et al. Essential differences in oncogene involvement between primary nodal and extranodal large cell lymphoma. Blood. 1991; 78:2680-5.

Specifications


  • Reactivity: paraffin
  • Visualization: membranous
  • Control: tonsil
  • Dilution Range: 1:10-1:50*

Package Inserts


IFU SDS

Ordering Information

For in vitro diagnostic (IVD) use in USA

0.1 mL concentrate123M-14
0.5 mL concentrate123M-15
1 mL concentrate123M-16
1 mL predilute123M-17
7 mL predilute123M-18

For in vitro diagnostic (IVD) use in Canada

0.1 mL concentrate123M-14
0.5 mL concentrate123M-15
1 mL concentrate123M-16
1 mL predilute123M-17
7 mL predilute123M-18

For in vitro diagnostic (IVD) use in Europe

0.1 mL concentrate123M-14
0.5 mL concentrate123M-15
1 mL concentrate123M-16
1 mL predilute123M-17
7 mL predilute123M-18

For research use only (RUO) in Japan

0.1 mL concentrate123M-14-RUO
0.5 mL concentrate123M-15-RUO
1 mL concentrate123M-16-RUO
1 mL predilute123M-17-RUO
7 mL predilute123M-18-RUO

 

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