SMAD4 (MRQ-72) Rabbit Monoclonal Antibody
Specialties: Gastrointestinal (GI) Pathology
Mothers Against Decapentaplegic Homolog 4 (SMAD4) is a transcription factor that is involved in TGFβ signaling pathways and acts as a tumor suppressor1. SMAD4 is commonly expressed in a variety of cancers, including pancreatic ductal adenocarcinoma (PDA), colorectal carcinoma (CRC), hepatocellular carcinoma (HCC), and gastric carcinomas, as well as non-neoplastic liver, pancreas, and colon2-5. However, a loss of expression has been observed in a subset of PDA, CRC and gastric carcinomas due to a variety of mutations including nonsense, missense, deletions, and splice site changes2-4,6. In contrast, SMAD4 is over-expressed in HCC compared to the weak expression that is exhibited in non-neoplastic liver5.
- Liu F, et al. Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes. Genes Dev 1997;11(23):3157-3167
- Ritterhouse LL, et al. Loss of SMAD4 protein expression in gastrointestinal and extra-gastrointestinal carcinomas. Histopath 2019;75(4):546-551
- Salovaara R, et al. Frequent loss of SMAD4/DPC4 protein in colorectal cancers. Gut 2002;51(1):56-59
- Kim YH, et al. Prognostic significance of the expression of Smad4 and Smad7 in human gastric carcinomas. Ann Oncol 2004;15(4):574-580
- Torbenson M, et al. Smad4 overexpression in hepatocellular carcinoma is strongly associated with transforming growth factor beta II receptor immunolabeling. Hum Pathol. 2002;33(9):871-876
- Woodford-Richens KL, et al. SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathway. Proc Natl Acad Sci USA 2001;98(17):9719-23
Specifications
- Reactivity: paraffin
- Control: Pancreas (Cytoplasmic, Nuclear)
- Dilution Range: 1:25-1:50 *
Package Inserts
IFU
- IVD Rev. 0.0 (CMC48739000)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 487R-94 |
| 0.5 mL concentrate | 487R-95 |
| 1.0 mL concentrate | 487R-96 |
| 1.0 mL predilute ready-to-use | 487R-97 |
| 7.0 mL predilute ready-to-use | 487R-98 |
For research use only (RUO) in Canada
| 0.1 mL concentrate (RUO) | 487R-94-RUO |
| 1.0 mL concentrate (RUO) | 487R-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 487R-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 487R-98-RUO |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 487R-94 |
| 0.5 mL concentrate | 487R-95 |
| 1.0 mL concentrate | 487R-96 |
| 1.0 mL predilute ready-to-use | 487R-97 |
| 7.0 mL predilute ready-to-use | 487R-98 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 487R-94-RUO |
| 1.0 mL concentrate (RUO) | 487R-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 487R-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 487R-98-RUO |
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