SDHB (EP288) Rabbit Monoclonal Primary Antibody
Specialties: Anatomic Pathology Gastrointestinal (GI) Pathology
Succinate dehydrogenase B (SDHB) is an iron-sulfur subunit of mitochondrial complex II, a respiratory complex that catalyzes the oxidation of succinate in the mitochondrial membrane1-2. Many cancers are generally positive for SDHB, including renal cell carcinomas (RCC) and gastrointestinal stromal tumors (GIST). However, a subset of RCC and GIST tumors that are associated with SDH mutations, Carney-Stratakis Syndrome or Carney Triad exhibit a loss of SDHB expression3-4.
- Au HC, et al. Structural organization of the gene encoding the human iron-sulfur subunit of succinate dehydrogenase. Gene. 1995; 159(2):249-253
- Gill AJ, et al. Immunohistochemistry for SDHB triages genetic testing of SDHB, SDHC, and SDHD in paraganglioma-pheochromocytoma syndromes. Hum Pathol. 2010; 41(6):805-814
- Williamson SR, et al. Succinate dehydrogenase-deficient renal cell carcinoma: detailed characterization of 11 tumors defining a unique subtype of renal cell carcinoma. Mod Pathol. 2015; 28(1):80-94
- Gaal J, et al. SDHB immunohistochemistry: a useful tool in the diagnosis of Carney-Stratakis and Carney triad gastrointestinal stromal tumors. Mod Pathol. 2011; 24(1):147-51
Specifications
- Reactivity: paraffin
- Control: Gastrointestinal stromal tumor (Cytoplasmic)
- Dilution Range: 1:25-1:100 *
Package Inserts
IFU
- IVD Rev. 0.0 (CMC46631000)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 466R-14 |
| 0.5 mL concentrate | 466R-15 |
| 1.0 mL concentrate | 466R-16 |
| 1.0 mL predilute ready-to-use | 466R-17 |
| 7.0 mL predilute ready-to-use | 466R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 466R-14 |
| 0.5 mL concentrate | 466R-15 |
| 1.0 mL concentrate | 466R-16 |
| 1.0 mL predilute ready-to-use | 466R-17 |
| 7.0 mL predilute ready-to-use | 466R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 466R-14 |
| 0.5 mL concentrate | 466R-15 |
| 1.0 mL concentrate | 466R-16 |
| 1.0 mL predilute ready-to-use | 466R-17 |
| 7.0 mL predilute ready-to-use | 466R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 466R-14-RUO |
| 0.5 mL concentrate (RUO) | 466R-15-RUO |
| 1.0 mL concentrate (RUO) | 466R-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 466R-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 466R-18-RUO |
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