DOG1 (SP31) Rabbit Monoclonal Antibody
Specialties: Anatomic Pathology Gastrointestinal (GI) Pathology
DOG1 is a calcium-dependent chloride channel protein that is encoded by a gene called TMEM16A (TMEM16 FLJ10261, ANO1, ORAOV2, and AOS2) located on chromosome 11q13.1 DOG1 has many significant functions such as regulation of the cholinergic activity of gastrointestinal smooth muscle 2, 3 and regulation of both the survival and proliferation of cells.4 Anti-DOG1 antibody has been shown to be useful in the identification of gastrointestinal stromal tumors (GIST).5
- Kang HG, et al. DOG1 and PKC-θ are useful in the diagnosis of KIT-negative gastrointestinal stromal tumors. Mod Pathol. 2011; 24:866-77.
- Rizzo FM, et al.Parallelism of DOG1 expression with recurrence risk in gastrointestinal stromal tumors bearing KIT or PDGFRA mutations. BMC Cancer. 2016; 16:87
- Katoh M, et al. FLJ10261 gene, located within the CCND1- EMS1 locus on human chromosome 1q13, encodes the eighttransmembrane protein homologous to C12orf3, C11orf25 and LJ34272 gene products. Int J Oncol. 2003; 22:1375-81.
- Stanich JE, et al. Ano1 as a regulator of proliferation. Am J Physiol Gastrointest Liver Physiol. 2011; 1044-51.
- Guler B, et al. Histopathological features of gastrointestinal stromal tumors and the contribution of DOG1 expression to the diagnosis. Balkan Med J. 2015; 32:388-96.
Specifications
- Reactivity: paraffin
- Control: Gastrointestinal Stromal Tumor (Cytoplasmic, Membranous)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 6.0 (CMC24431060)
Have a different keycode?
Click Here
Learn how to obtain your SDS
Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 244R-14 |
| 0.5 mL concentrate | 244R-15 |
| 1.0 mL concentrate | 244R-16 |
| 1.0 mL predilute ready-to-use | 244R-17 |
| 7.0 mL predilute ready-to-use | 244R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 244R-14 |
| 0.5 mL concentrate | 244R-15 |
| 1.0 mL concentrate | 244R-16 |
| 1.0 mL predilute ready-to-use | 244R-17 |
| 7.0 mL predilute ready-to-use | 244R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 244R-14 |
| 0.5 mL concentrate | 244R-15 |
| 1.0 mL concentrate | 244R-16 |
| 1.0 mL predilute ready-to-use | 244R-17 |
| 7.0 mL predilute ready-to-use | 244R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 244R-14-RUO |
| 0.5 mL concentrate (RUO) | 244R-15-RUO |
| 1.0 mL concentrate (RUO) | 244R-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 244R-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 244R-18-RUO |
To request information on this product in additional countries, please click the button below.
