p120 Catenin (MRQ-5) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology Breast/Gynecological Pathology
p120 catenin is encoded on chromosome 11q11. Alpha-catenin and beta-catenin bind to the intracellular domain of E-cadherin while p120 catenin binds E-cadherin at a juxta-membrane site.1 The complex stabilizes tight junctions. In the cell, p120 catenin localized to the E-cadherin/catenins cell adhesion complex, directly associates with cytoplasmic C-terminus of E-cadherin and may similarly interact with other cadherins.2 A deficiency of E-cadherin results in the intracytoplasmic accumulation of p120 catenin. Lobular carcinoma of the breast shows intracytoplasmic accumulation of p120 catenin while ductal carcinoma shows reduced membrane p120 catenin without cytoplasmic accumulation.3,4 In gastric and colonic carcinoma, strong cytoplasmic p120 catenin is associated with discohesive infiltrative morphology.5
- Reynolds AB, et al. p120, a novel substrate of protein tyrosine kinase receptors and of p60v-src, is related to cadherin-binding factors beta-catenin, plakoglobin and armadillo. Oncogene. 1992; 7:2439-45.
- Thoreson MA, et al. Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion. J Cell Biol. 2000; 148:189-202.
- Sarrio D, et al. Cytoplasmic localization of p120ctn and E-cadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions. Oncogene. 2004; 23:3272-83.
- Dabbs DJ, et al. Lobular versus ductal breast neoplasms: the diagnostic utility of p120 catenin. Am J Surg Pathol. 2007; 31:427-37.
- Jawhari AU, et al. Up-regulated cytoplasmic expression, with reduced membranous distribution, of the src substrate p120 (ctn) in gastric carcinoma. J Pathol. 1999; 189:180-5.
Specifications
- Reactivity: paraffin
- Control: Breast lobular carcinoma (Cytoplasmic, Membranous)
- Dilution Range: 1:50-1:200 *
Package Inserts
IFU
- IVD Rev. 5.0 (CMC42021050)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 420M-10 |
| 0.1 mL concentrate | 420M-14 |
| 0.5 mL concentrate | 420M-15 |
| 1.0 mL concentrate | 420M-16 |
| 1.0 mL predilute ready-to-use | 420M-17 |
| 7.0 mL predilute ready-to-use | 420M-18 |
For in vitro diagnostic (IVD) use in Canada
| 25.0 mL predilute ready-to-use | 420M-10 |
| 0.1 mL concentrate | 420M-14 |
| 0.5 mL concentrate | 420M-15 |
| 1.0 mL concentrate | 420M-16 |
| 1.0 mL predilute ready-to-use | 420M-17 |
| 7.0 mL predilute ready-to-use | 420M-18 |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 420M-10 |
| 0.1 mL concentrate | 420M-14 |
| 0.5 mL concentrate | 420M-15 |
| 1.0 mL concentrate | 420M-16 |
| 1.0 mL predilute ready-to-use | 420M-17 |
| 7.0 mL predilute ready-to-use | 420M-18 |
For research use only (RUO) in Japan
| 25.0 mL predilute ready-to-use (RUO) | 420M-10-RUO |
| 0.1 mL concentrate (RUO) | 420M-14-RUO |
| 0.5 mL concentrate (RUO) | 420M-15-RUO |
| 1.0 mL concentrate (RUO) | 420M-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 420M-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 420M-18-RUO |
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