P504s (13H4) Rabbit Monoclonal Antibody
Specialties: Genitourinary (GU) Pathology
Detection of P504s by immunohistochemistry (IHC) with P504s (13H4) Rabbit Monoclonal Antibody may be used to aid in the diagnosis of prostate carcinoma.
P504s, or alpha-methylacyl-CoA racemase (AMACR), is a mitochondrial and peroxisomal enzyme that is essential for lipid metabolism.1,2 P504s expression is found normally in many benign tissues including the liver, kidney, and gastrointestinal tract, but not the prostate.3 P504s expression has also been found in most prostate carcinomas, but rarely in benign prostate tissue.1-5 Immunohistochemistry for p504s shows a granular cytoplasmic pattern of staining.
- Jiang, Z et al. "P504S: a new molecular marker for the detection of prostate carcinoma." The American journal of surgical pathology vol. 25,11 (2001): 1397-404.
- Jiang, Zhong et al. "P504S/alpha-methylacyl- CoA racemase: a useful marker for diagnosis of small foci of prostatic carcinoma on needle biopsy." The American journal of surgical pathology vol. 26,9 (2002): 1169-74.
- Jiang, Zhong et al. "Expression of alpha-methylacyl- CoA racemase (P504s) in various malignant neoplasms and normal tissues: astudy of 761 cases." Human pathology vol. 34,8 (2003): 792-6.
- Evans AJ. Alpha-methylacyl CoA racemase (P504S): overview and potential uses in diagnostic pathology as applied to prostate needle biopsies. J Clin Pathol. 2003 Dec;56(12):892- 7.
- Zhou, Ming et al. "Alpha-Methylacyl-CoA racemase: a novel tumor marker over-expressed in several human cancers and their precursor lesions." The American journal of surgical pathology vol. 26,7 (2002): 926-31.
- Nadji M, Morales AR. Immunoperoxidase, part I: the techniques and its pitfalls. Lab Med 1983;14:767
- Omata M, Liew CT, Ashcavai M, Peters RL. Nonimmunologic binding of horseradish peroxidase to hepatitis B surface antigen. A possible source of error in immunohistochemistry. Am J Clin Pathol. 1980 May; 73(5):626-32. doi: 10.1093/ajcp/73.5.626. PMID: 6155065.
Specifications
- Reactivity: paraffin
- Control: Prostate adenocarcinoma (Cytoplasmic)
- Dilution Range: 1:50-1:200 *
Package Inserts
IFU
- IVD Rev. 2.0 (CMC50431020)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 504R-10 |
| 0.1 mL concentrate | 504R-14 |
| 0.5 mL concentrate | 504R-15 |
| 1.0 mL concentrate | 504R-16 |
| 1.0 mL predilute ready-to-use | 504R-17 |
| 7.0 mL predilute ready-to-use | 504R-18 |
For in vitro diagnostic (IVD) use in Canada
| 25.0 mL predilute ready-to-use | 504R-10 |
| 0.1 mL concentrate | 504R-14 |
| 0.5 mL concentrate | 504R-15 |
| 1.0 mL concentrate | 504R-16 |
| 1.0 mL predilute ready-to-use | 504R-17 |
| 7.0 mL predilute ready-to-use | 504R-18 |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 504R-10 |
| 0.1 mL concentrate | 504R-14 |
| 0.5 mL concentrate | 504R-15 |
| 1.0 mL concentrate | 504R-16 |
| 1.0 mL predilute ready-to-use | 504R-17 |
| 7.0 mL predilute ready-to-use | 504R-18 |
For research use only (RUO) in Japan
| 25.0 mL predilute ready-to-use (RUO) | 504R-10-RUO |
| 0.1 mL concentrate (RUO) | 504R-14-RUO |
| 0.5 mL concentrate (RUO) | 504R-15-RUO |
| 1.0 mL concentrate (RUO) | 504R-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 504R-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 504R-18-RUO |
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