Arginase-1 (SP156) Rabbit Monoclonal Antibody
Specialties: Anatomic Pathology Gastrointestinal (GI) Pathology
Detection of arginase-1 by immunohistochemistry (IHC) with Arginase-1 (SP156) Rabbit Monoclonal Antibody may be used to aid in the diagnosis of hepatocellular carcinoma.1,2
Arginase is a key metalloenzyme of the urea cycle responsible for the hydrolysis of L-arginine to L-ornithine and urea.3 Two main isoforms exist, arginase-1 and arginase-2, encoded by different genes and with different tissue distributions. The arginase-1 isoform is a cytosolic protein that is produced by normal liver tissue and is typically expressed in hepatocellular carcinoma.1,3,4
In combination with other antibodies, this product may be used as an aid in diagnosis.
- Yan, Benjamin C et al. Arginase-1: a new immunohistochemical marker of hepatocytes and hepatocellular neoplasms.The American journal of surgical pathology vol. 34,8 (2010): 1147-54.
- Clark, Ian et al. subset of well-differentiated hepatocellular carcinomas are Arginase-1 negative. Human pathology vol. 69 (2017): 90-95.
- McKnight, Ryan et al. Arginase-1: a novel immunohistochemical marker of hepatocellular differentiation in fine needle aspiration cytology. Cancer cytopathology vol. 120,4 (2012): 223-9.
- Sang, Wei et al. Arginase-1 is a more sensitive marker than HepPar-1 and AFP in differential diagnosis of hepatocellular carcinoma from nonhepatocellular carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine vol. 36,5 (2015): 3881-6.
- Nadji M, Morales AR. Immunoperoxidase, part I: the techniques and its pitfalls. Lab Med 1983;14:767
- Omata M, Liew CT, Ashcavai M, Peters RL. Non immunologic binding of horseradish peroxidase to hepatitis B surface antigen. A possible source of error in immunohistochemistry. Am J Clin Pathol. 1980 May; 73(5):626-32. doi: 10.1093/ ajcp/73.5.626. PMID: 6155065.
Specifications
- Reactivity: paraffin
- Control: Normal Liver (Cytoplasmic, Nuclear); Hepatocellular Carcinoma (Cytoplasmic, Nuclear)
- Dilution Range: 1:25-1:100 *
Package Inserts
IFU
- IVD Rev. 4.0 (CMC38031040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 380R-10 |
| 0.1 mL concentrate | 380R-14 |
| 0.5 mL concentrate | 380R-15 |
| 1.0 mL concentrate | 380R-16 |
| 1.0 mL predilute ready-to-use | 380R-17 |
| 7.0 mL predilute ready-to-use | 380R-18 |
For in vitro diagnostic (IVD) use in Canada
| 25.0 mL predilute ready-to-use | 380R-10 |
| 0.1 mL concentrate | 380R-14 |
| 0.5 mL concentrate | 380R-15 |
| 1.0 mL concentrate | 380R-16 |
| 1.0 mL predilute ready-to-use | 380R-17 |
| 7.0 mL predilute ready-to-use | 380R-18 |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 380R-10 |
| 0.1 mL concentrate | 380R-14 |
| 0.5 mL concentrate | 380R-15 |
| 1.0 mL concentrate | 380R-16 |
| 1.0 mL predilute ready-to-use | 380R-17 |
| 7.0 mL predilute ready-to-use | 380R-18 |
For research use only (RUO) in Japan
| 25.0 mL predilute ready-to-use (RUO) | 380R-10-RUO |
| 0.1 mL concentrate (RUO) | 380R-14-RUO |
| 0.5 mL concentrate (RUO) | 380R-15-RUO |
| 1.0 mL concentrate (RUO) | 380R-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 380R-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 380R-18-RUO |
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