Arginase-1 (SP156) Rabbit Monoclonal Antibody
Specialties: Anatomic Pathology Gastrointestinal (GI) Pathology
Detection of arginase-1 by immunohistochemistry (IHC) with Arginase-1 (SP156) Rabbit Monoclonal Antibody may be used to aid in the diagnosis of hepatocellular carcinoma.1,2
Arginase is a key metalloenzyme of the urea cycle responsible for the hydrolysis of L-arginine to L-ornithine and urea.3 Two main isoforms exist, arginase-1 and arginase-2, encoded by different genes and with different tissue distributions. The arginase-1 isoform is a cytosolic protein that is produced by normal liver tissue and is typically expressed in hepatocellular carcinoma.1,3,4
- Yan, Benjamin C et al. "Arginase-1: a new immunohistochemical marker of hepatocytes and hepatocellular neoplasms." The American journal of surgical pathology vol. 34,8 (2010): 1147-54.
- Clark, Ian et al. "A subset of well-differentiated hepatocellular carcinomas are Arginase-1 negative." Human pathology vol. 69 (2017): 90-95.
- McKnight, Ryan et al. "Arginase-1: a novel immunohistochemical marker of hepatocellular differentiation in fine needle aspiration cytology." Cancer cytopathology vol. 120,4 (2012): 223-9.
- Sang, Wei et al. "Arginase-1 is a more sensitive marker than HepPar-1 and AFP in differential diagnosis of hepatocellular carcinoma from nonhepatocellular carcinoma." Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine vol. 36,5 (2015): 3881-6.
- Nadji M, Morales AR. "Immunoperoxidase, part I: the techniques and its pitfalls." Lab Med 1983;14:767
- Omata M, Liew CT, Ashcavai M, Peters RL. "Nonimmunologic binding of horseradish peroxidase to hepatitis B surface antigen. A possible source of error in immunohistochemistry."Am J Clin Pathol. 1980 May; 73(5):626-32. doi: 10.1093/ ajcp/73.5.626. PMID: 6155065.
Specifications
- Reactivity: paraffin
- Control: Normal Liver (Cytoplasmic, Nuclear); Hepatocellular Carcinoma (Cytoplasmic, Nuclear)
- Dilution Range: 1:25-1:100 *
Package Inserts
IFU
- IVD Rev. 4.0 (CMC38031040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 380R-10 |
| 0.1 mL concentrate | 380R-14 |
| 0.5 mL concentrate | 380R-15 |
| 1.0 mL concentrate | 380R-16 |
| 1.0 mL predilute ready-to-use | 380R-17 |
| 7.0 mL predilute ready-to-use | 380R-18 |
For in vitro diagnostic (IVD) use in Canada
| 25.0 mL predilute ready-to-use | 380R-10 |
| 0.1 mL concentrate | 380R-14 |
| 0.5 mL concentrate | 380R-15 |
| 1.0 mL concentrate | 380R-16 |
| 1.0 mL predilute ready-to-use | 380R-17 |
| 7.0 mL predilute ready-to-use | 380R-18 |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 380R-10 |
| 0.1 mL concentrate | 380R-14 |
| 0.5 mL concentrate | 380R-15 |
| 1.0 mL concentrate | 380R-16 |
| 1.0 mL predilute ready-to-use | 380R-17 |
| 7.0 mL predilute ready-to-use | 380R-18 |
For research use only (RUO) in Japan
| 25.0 mL predilute ready-to-use (RUO) | 380R-10-RUO |
| 0.1 mL concentrate (RUO) | 380R-14-RUO |
| 0.5 mL concentrate (RUO) | 380R-15-RUO |
| 1.0 mL concentrate (RUO) | 380R-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 380R-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 380R-18-RUO |
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