MUC1 (MRQ-17) Mouse Monoclonal Antibody
Specialties: Gastrointestinal (GI) Pathology
Mucins are high molecular weight glycoproteins which constitute the major component of the mucus layer that protects the gastric epithelium from chemical and mechanical injury. In humans, at least 14 mucin genes have been identified that code for the mucin proteins. Mucin genes are expressed in a regulated cell- and tissue-specific manner. The stomach provides a good example of such differential expression of mucin genes. MUC1 is detected in mucous cells of the surface epithelium and neck region of the gastric antrum, as well as in pyloric glands and oxyntic glands of the body region. The heterogeneous pattern of mucin expression, including the expression of the intestinal mucin MUC2, may provide new insights into the differentiation pathways of gastric carcinoma.1-5
- Chaves P, et al. Gastric and intestinal differentiation in Barrett’s metaplasia and associated adenocarcinoma. Dis Esophagus. 2005; 18:383-7.
- Leteurtre E, et al. Relationships between mucinous gastric carcinoma, MUC2 expression and survival. World J Gastroenterol. 2006; 12:3324-31.
- Mino-Kenudson M, et al. Mucin expression in reactive gastropathy: an immunohistochemical analysis. Arch Pathol Lab Med. 2007; 131:86-90.
- Mizoshita T, et al. Loss of MUC2 expression correlates with progression along the adenoma-carcinoma sequence pathway as well as de novo carcinogenesis in the colon. Histol Histopathol. 2007; 22:251-60.
- O’Connell FP, et al. Utility of immunohistochemistry in distinguishing primary adenocarcinomas from metastatic breast carcinomas in the gastrointestinal tract. Arch Pathol Lab Med. 2005; 129:338-47.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic
- Control: breast, colon, associated adenocarcinomas
- Dilution Range: 1:50-1:200*
Package Inserts
IFU
- IVD Rev. 4.0 (CMC29021040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 290M-14 |
| 0.5 mL concentrate | 290M-15 |
| 1 mL concentrate | 290M-16 |
| 1 mL predilute | 290M-17 |
| 7 mL predilute | 290M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 290M-14 |
| 0.5 mL concentrate | 290M-15 |
| 1 mL concentrate | 290M-16 |
| 1 mL predilute | 290M-17 |
| 7 mL predilute | 290M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 290M-14 |
| 0.5 mL concentrate | 290M-15 |
| 1 mL concentrate | 290M-16 |
| 1 mL predilute | 290M-17 |
| 7 mL predilute | 290M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 290M-14-RUO |
| 0.5 mL concentrate | 290M-15-RUO |
| 1 mL concentrate | 290M-16-RUO |
| 1 mL predilute | 290M-17-RUO |
| 7 mL predilute | 290M-18-RUO |
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