MUC5AC (MRQ-19) Mouse Monoclonal Antibody
Specialties: Gastrointestinal (GI) Pathology
MUC5AC is a high molecular weight glycoprotein classified as a secreted mucin produced by epithelial cells.1,2 MUC5AC is preferentially expressed in non-neoplastic gastric tissue and benign respiratory tract tissue.1 During neoplastic transformation, mucin expression may be altered within these tissues leading to particular patterns of expression.1 Cytoplasmic expression of MUC5AC can be seen in adenocarcinomas of the gastrointestinal tract, particularly those of esophagus and stomach, as well as the pancreatobiliary tract including cholangiocarcinomas.1 Other tumors expressing MUC5AC include carcinomas of the endometrium and lung.1 MUC5AC may also be seen in Paget’s disease.3
- Lau SK, Weiss LM, Chu PG. Differential expression of MUC1, MUC2, and MUC5AC in carcinomas of various sites: an immunohistochemical study. Am J Clin Pathol. 2004 Jul;122(1):61-9.
- Moschovis D, Bamias G, Delladetsima I. Mucins in neoplasms of pancreas, ampulla of Vater and biliary system. World J Gastrointest Oncol. 2016 Oct 15;8(10):725-734.
- Kuan SF, Montag AG, Hart J, Krausz T, Recant W. Differential expression of mucin genes in mammary and extramammary Paget's disease. Am J Surg Pathol. 2001 Dec;25(12):1469-77.
Specifications
- Reactivity: paraffin
- Control: Stomach (Cytoplasmic)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 5.0 (CMC29229050)
Have a different keycode?
Click Here
Learn how to obtain your SDS
Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.5 mL concentrate | 292M-95 |
| 1.0 mL concentrate | 292M-96 |
| 1.0 mL predilute ready-to-use | 292M-97 |
| 7.0 mL predilute ready-to-use | 292M-98 |
For in vitro diagnostic (IVD) use in Canada
| 0.5 mL concentrate | 292M-95 |
| 1.0 mL concentrate | 292M-96 |
| 1.0 mL predilute ready-to-use | 292M-97 |
| 7.0 mL predilute ready-to-use | 292M-98 |
For in vitro diagnostic (IVD) use in Europe
| 0.5 mL concentrate | 292M-95 |
| 1.0 mL concentrate | 292M-96 |
| 1.0 mL predilute ready-to-use | 292M-97 |
| 7.0 mL predilute ready-to-use | 292M-98 |
For research use only (RUO) in Japan
| 0.5 mL concentrate (RUO) | 292M-95-RUO |
| 1.0 mL concentrate (RUO) | 292M-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 292M-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 292M-98-RUO |
To request information on this product in additional countries, please click the button below.
