Malignant melanoma demonstrates nuclear staining by SOX-10 antibody.
SOX-10 (EP268) Rabbit Monoclonal Primary Antibody
Specialties: Dermatopathology
Updated: 2023-01-05 15:07:53
Sry-related HMG-BOX gene 10, SOX-10, is a transcription factor involved in neural crest and peripheral nervous system development, and acts as a nucleocytoplasmic shuttle protein.1 SOX-10 is expressed in melanocytic lineages, and is a sensitive marker of melanoma for conventional, and desmoplastic subtypes.2-3 In normal tissues, SOX-10 is expressed in melanocytes, and myoepithelial cells.4
- Rehberg S, et al. Sox10 is an active nucleocytoplasmic shuttle protein, and shuttling is crucial for Sox10-mediated transactivation. Mol Cell Biol. 2002; 22:5826-34.
- Nonaka D, et al. Sox10: a pan-schwannian and melanocytic marker. Am J Surg Pathol. 2008; 32:1291-8.
- Nielsen TO, et al. Sox10 and S100 in the diagnosis of soft-tissue neoplasms. Appl Immunohistochem Mol Morphol. 2012; 20:445-50.
- Miettinen M, et al. Sox10--a marker for not only schwannian and melanocytic neoplasms but also myoepithelial cell tumors of soft tissue: a systematic analysis of 5134 tumors. Am J Surg Pathol. 2015; 39:826-35.
Specifications
- Reactivity: paraffin
- Control: Melanoma (Nuclear); Skin Melanocytes (Nuclear)
- Dilution Range: 1:50-1:200 *
Package Inserts
IFU
- IVD Rev. 4.0 (CMC38331040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 383R-10 |
| 0.1 mL concentrate | 383R-14 |
| 0.5 mL concentrate | 383R-15 |
| 1.0 mL concentrate | 383R-16 |
| 1.0 mL predilute ready-to-use | 383R-17 |
| 7.0 mL predilute ready-to-use | 383R-18 |
For in vitro diagnostic (IVD) use in Canada
| 25.0 mL predilute ready-to-use | 383R-10 |
| 0.1 mL concentrate | 383R-14 |
| 0.5 mL concentrate | 383R-15 |
| 1.0 mL concentrate | 383R-16 |
| 1.0 mL predilute ready-to-use | 383R-17 |
| 7.0 mL predilute ready-to-use | 383R-18 |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 383R-10 |
| 0.1 mL concentrate | 383R-14 |
| 0.5 mL concentrate | 383R-15 |
| 1.0 mL concentrate | 383R-16 |
| 1.0 mL predilute ready-to-use | 383R-17 |
| 7.0 mL predilute ready-to-use | 383R-18 |
For research use only (RUO) in Japan
| 25.0 mL predilute ready-to-use (RUO) | 383R-10-RUO |
| 0.1 mL concentrate (RUO) | 383R-14-RUO |
| 0.5 mL concentrate (RUO) | 383R-15-RUO |
| 1.0 mL concentrate (RUO) | 383R-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 383R-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 383R-18-RUO |
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