Fascin (55k-2) on lymph node.
Fascin (55k-2) Mouse Monoclonal Antibody
Specialties: Hematopathology
Updated: 2017-05-24 08:46:09
Fascin is a 55-kd actin bundling protein involved in cell migration. Fascin is up-regulated in many human carcinomas and numerous studies have correlated Fascin over-expression with increased metastatic potential.1-2 Fascin is highly sensitive for staining Reed-Sternberg cells making it an excellent marker for classic Hodgkin’s lymphoma.3
- Hashimoto Y, et al. Roles of fascin in human carcinoma motility and signaling: prospects for a novel biomarker? Int J Biochem Cell Biol. 2005; 37:1787-804.
- Tan VY, et al. Association of fascin-1 with mortality, disease progression and metastasis in carcinomas: a systematic review and meta-analysis. BMC Med. 2013; 11:52.
- Pinkus GS, et al. Fascin, a sensitive new marker for Reed-Sternberg cells of hodgkin's disease. Evidence for a dendritic or B cell derivation? Am J Pathol. 1997; 150:543-62.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic
- Control: Hodgkin's lymphoma
- Dilution Range: 1:100-1:500*
Package Inserts
IFU
- IVD Rev. 4.0 (CMC25221040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 252M-14 |
| 0.5 mL concentrate | 252M-15 |
| 1 mL concentrate | 252M-16 |
| 1 mL predilute | 252M-17 |
| 7 mL predilute | 252M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 252M-14 |
| 0.5 mL concentrate | 252M-15 |
| 1 mL concentrate | 252M-16 |
| 1 mL predilute | 252M-17 |
| 7 mL predilute | 252M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 252M-14 |
| 0.5 mL concentrate | 252M-15 |
| 1 mL concentrate | 252M-16 |
| 1 mL predilute | 252M-17 |
| 7 mL predilute | 252M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 252M-14-RUO |
| 0.5 mL concentrate | 252M-15-RUO |
| 1 mL concentrate | 252M-16-RUO |
| 1 mL predilute | 252M-17-RUO |
| 7 mL predilute | 252M-18-RUO |
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