Oct-2 (MRQ-2) Mouse Monoclonal Antibody
Specialties: Hematopathology
Octamer-binding transcription factor-2 (Oct-2) is a transcription factor of the POU homeo-domain family. It binds to Ig gene octamer sites and plays a crucial role in B-cell development and differentiation, as well as in B-cell identity.1 Oct-2 is expressed in a subset of normal B-lymphocytes and is expressed in various B-cell lymphomas as well as nodular lymphocyte predominant Hodgkin lymphoma, while it is typically not expressed in the Reed–Sternberg and Hodgkin (RS/H) cells of classical Hodgkin lymphoma.1-3
- Browne, Patrick et al. "The B-cell transcription factors BSAP, Oct-2, and BOB.1 and the pan-B-cell markers CD20, CD22, and CD79a are useful in the differential diagnosis of classic Hodgkin lymphoma." American journal of clinical pathology vol. 120,5 (2003): 767-77.
- García-Cosío, Mónica et al. "Analysis of transcription factor OCT.1, OCT.2 and BOB.1 expression using tissue arrays in classical Hodgkin's lymphoma." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc vol. 17,12 (2004): 1531-8.
- Gibson, Sarah E et al. "Expression of the B cell-associated transcription factors PAX5, OCT-2, and BOB.1 in acute myeloid leukemia: associations with B-cell antigen expression and myelomonocytic maturation." American journal of clinical pathology vol. 126,6 (2006): 916-24.
Specifications
- Reactivity: paraffin
- Control: Tonsil (Nuclear); Lymph node (Nuclear)
- Dilution Range: 1:25-1:100 *
Package Inserts
IFU
- IVD Rev. 4.0 (CMC30821040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 308M-14 |
| 0.5 mL concentrate | 308M-15 |
| 1.0 mL concentrate | 308M-16 |
| 1.0 mL predilute ready-to-use | 308M-17 |
| 7.0 mL predilute ready-to-use | 308M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 308M-14 |
| 0.5 mL concentrate | 308M-15 |
| 1.0 mL concentrate | 308M-16 |
| 1.0 mL predilute ready-to-use | 308M-17 |
| 7.0 mL predilute ready-to-use | 308M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 308M-14 |
| 0.5 mL concentrate | 308M-15 |
| 1.0 mL concentrate | 308M-16 |
| 1.0 mL predilute ready-to-use | 308M-17 |
| 7.0 mL predilute ready-to-use | 308M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 308M-14-RUO |
| 0.5 mL concentrate | 308M-15-RUO |
| 1.0 mL concentrate (RUO) | 308M-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 308M-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 308M-18-RUO |
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