Cytokeratin (35betaH11) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology
Cytokeratin 8, a member of the Type II family of cytokeratins, is typically expressed in simple epithelium. The dimerization of cytokeratin 8 with cytokeratin 18 (labeled by 35betaH11) in the cytoplasm of simple epithelial cells allows for the formation of an intermediate filament cytoskeletal framework. This structure plays a role in the maintenance of cellular structural integrity and also functions in promoting signal transduction and cellular differentiation processes.1 Additionally, the presence of cytokeratin 8 has been detected in neoplastic epithelia, including glandular epithelium that can be found in prostate carcinoma.2 Positive immunoreactivity with anti-cytokeratin 8 is a useful indicator for the identification of normal and neoplastic epithelial tissues.2,3
- Moll R, et al. The human keratins: biology and pathology. Histochem Cell Biol. 2008; 129:705-33.
- Ljung G, et al. Characterization of residual tumor cells following radical radiation therapy for prostatic adenocarcinoma; immunohistochemical expression of prostate-specific antigen, prostatic acid phosphatase, and cytokeratin 8. Prostate. 1997; 31:91-7.
- Murata T, et al. The diagnostic use of low molecular weight keratin expression in sebaceous carcinoma. Pathol Res Pract. 1993; 189:888-93.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic
- Control: prostate
- Dilution Range: 1:100-1:500*
Package Inserts
IFU
- IVD Rev. 4.0 (CMC33529040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 335M-94 |
| 0.5 mL concentrate | 335M-95 |
| 1 mL concentrate | 335M-96 |
| 1 mL predilute | 335M-97 |
| 7 mL predilute | 335M-98 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 335M-94 |
| 0.5 mL concentrate | 335M-95 |
| 1 mL concentrate | 335M-96 |
| 1 mL predilute | 335M-97 |
| 7 mL predilute | 335M-98 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 335M-94 |
| 0.5 mL concentrate | 335M-95 |
| 1 mL concentrate | 335M-96 |
| 1 mL predilute | 335M-97 |
| 7 mL predilute | 335M-98 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 335M-94-RUO |
| 0.5 mL concentrate | 335M-95-RUO |
| 1 mL concentrate | 335M-96-RUO |
| 1 mL predilute | 335M-97-RUO |
| 7 mL predilute | 335M-98-RUO |
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