Cytokeratin Cocktail (AE1 & AE3) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology
Detection of cytokeratins by immunohistochemistry (IHC) with Cytokeratin Cocktail (AE1 & AE3) Mouse Monoclonal Antibody may be used to aid in the diagnosis of carcinomas, which are malignancies arising from epithelial cells.
Cytokeratin Cocktail (AE1 & AE3) is composed of two mouse monoclonal antibodies, AE1 and AE3, which together react with many cytokeratins, a large family of intermediate filament proteins that are only produced by epithelial cells.1,3 Cytokeratin Cocktail (AE1 & AE3) reacts with all types of epithelia including keratinized epidermis, stratified squamous epithelia of internal organs, other stratified epithelia, and simple epithelia.1 Immunohistochemistry with Cytokeratin Cocktail (AE1 & AE3) is positive in carcinomas, regardless of primary site, but not other malignancies.1-5 Immunohistochemistry for Cytokeratin Cocktail (AE1 & AE3) shows a cytoplasmic pattern of staining.
In combination with other antibodies, this product may be used as an aid in diagnosis.
- Moll, R et al."The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells."Cell vol. 31,1 (1982): 11-24.
- Wick, M R et al."Placental-like alkaline phosphatase reactivity in human tumors: an immunohistochemical study of 520 cases."Human pathology vol. 18,9 (1987): 946-54.
- Listrom, M B, and L W Dalton."Compari son of keratin monoclonal antibodies MAK-6, AE1:AE3, and CAM-5.2."American journal of clinical pathology vol. 88,3 (1987): 297 301.
- Lyda, M H, and L M Weiss."Immunoreactivity for epithelial and neuroendocrine antibodies are useful in the differential diagnosis of lung carcinomas."Human pathology vol. 31,8 (2000): 980-7.
- Gown, A M, and A M Vogel."Monoclonal antibodies to human intermediate filament proteins. III. Analysis of tumors." American journal of clinical pathology vol. 84,4 (1985): 413-24.
- Nadji M, Morales AR. Immunoperoxidase, part I: the techniques and its pitfalls. Lab Med 1983;14:767
- Omata M, Liew CT, Ashcavai M, Peters RL. Nonimmunologic binding of horseradish peroxidase to hepatitis B surface antigen. A possible source of error in immunohistochemistry. Am J Clin Pathol. 1980 May; 73(5):626-32. doi: 10.1093/ajcp/73.5.626. PMID: 6155065.
Specifications
- Reactivity: paraffin
- Control: Breast (Cytoplasmic); Lung (Cytoplasmic); Colon (Cytoplasmic); Skin (Cytoplasmic)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 7.0 (CMC31321070)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 313M-10 |
| 0.1 mL concentrate | 313M-14 |
| 0.5 mL concentrate | 313M-15 |
| 1.0 mL concentrate | 313M-16 |
| 1.0 mL predilute ready-to-use | 313M-17 |
| 7.0 mL predilute ready-to-use | 313M-18 |
| 15.0 mL predilute ready-to-use | 313M-19 |
For in vitro diagnostic (IVD) use in Canada
| 25.0 mL predilute ready-to-use | 313M-10 |
| 0.1 mL concentrate | 313M-14 |
| 0.5 mL concentrate | 313M-15 |
| 1.0 mL concentrate | 313M-16 |
| 1.0 mL predilute ready-to-use | 313M-17 |
| 7.0 mL predilute ready-to-use | 313M-18 |
| 15.0 mL predilute ready-to-use | 313M-19 |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 313M-10 |
| 0.1 mL concentrate | 313M-14 |
| 0.5 mL concentrate | 313M-15 |
| 1.0 mL concentrate | 313M-16 |
| 1.0 mL predilute ready-to-use | 313M-17 |
| 7.0 mL predilute ready-to-use | 313M-18 |
| 15.0 mL predilute ready-to-use | 313M-19 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 313M-14-RUO |
| 0.5 mL concentrate (RUO) | 313M-15-RUO |
| 1.0 mL concentrate (RUO) | 313M-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 313M-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 313M-18-RUO |
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