Ducts and acini of the salivary gland are labelled by anti-cytokeratin 8 & 18 in a cytoplasmic reaction.
Cytokeratin 8 & 18 (B22.1 & B23.1) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology
Updated: 2022-09-09 14:24:56
Cytokeratins 8 &18 (CK 8 & 18) are major components of the intermediate filaments in thyroid, liver and most simple epithelia (e.g. breast, gastrointestinal and respiratory tracts).1-2 Anti-CK 8 & 18 is found to stain most adenocarcinomas and squamous cell carcinomas.3-5 CK 8 & 18 are frequently used as the epithelial markers for identifying Paget cells,6 metastatic gastric7 and colorectal carcinomas.8
- Franke, W W et al. "Diversity of cytokeratins. Differentiation specific expression of cytokeratin polypeptides in epithelial cells and tissues." Journal of molecular biology vol. 153,4 (1981): 933-59.
- Oshima, R G et al. "Oncogenic regulation and function of keratins 8 and 18." Cancer metastasis reviews vol. 15,4 (1996): 445-71.
- Angus, B et al. "NCL-5D3: a new monoclonal antibody recognizing low molecular weight cytokeratins effective for immunohistochemistry using fixed paraffin-embedded tissue." The Journal of pathology vol. 153,4 (1987): 377-84.
- Corson, J M. "Keratin protein immunohistochemistry in surgical pathology practice." Pathology annual vol. 21 Pt 2 (1986): 47-81.
- Moll, Roland et al. "The human keratins: biology and pathology." Histochemistry and cell biology vol. 129,6 (2008): 705-33.
- Liegl, B et al. "Mammary and extramammary Paget's disease: an immunohistochemical study of 83 cases." Histopathology vol. 50,4 (2007): 439-47.
- Ishii, Kaname et al. "Detection of sentinel and non-sentinel lymph node micrometastases by complete serial sectioning and immunohistochemical analysis for gastric cancer." Journal of experimental & clinical cancer research : CR vol. 27,1 7. 30 May. 2008.
- Sasaki, M et al. "Immunoperoxidase staining for cytokeratins 8 and 18 is very sensitive for detection of occult node metastasis of colorectal cancer: a comparison with genetic analysis of K-ras." Histopathology vol. 32,3 (1998): 199-208.
Specifications
- Reactivity: paraffin
- Control: Prostate (Cytoplasmic); Pancreas (Cytoplasmic)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 8.0 (CMC81829080)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 818M-90 |
| 0.1 mL concentrate | 818M-94 |
| 0.5 mL concentrate | 818M-95 |
| 1.0 mL concentrate | 818M-96 |
| 1.0 mL predilute ready-to-use | 818M-97 |
| 7.0 mL predilute ready-to-use | 818M-98 |
For in vitro diagnostic (IVD) use in Canada
| 25.0 mL predilute ready-to-use | 818M-90 |
| 0.1 mL concentrate | 818M-94 |
| 0.5 mL concentrate | 818M-95 |
| 1.0 mL concentrate | 818M-96 |
| 1.0 mL predilute ready-to-use | 818M-97 |
| 7.0 mL predilute ready-to-use | 818M-98 |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 818M-90 |
| 0.1 mL concentrate | 818M-94 |
| 0.5 mL concentrate | 818M-95 |
| 1.0 mL concentrate | 818M-96 |
| 1.0 mL predilute ready-to-use | 818M-97 |
| 7.0 mL predilute ready-to-use | 818M-98 |
For research use only (RUO) in Japan
| 25.0 mL predilute ready-to-use (RUO) | 818M-90-RUO |
| 0.1 mL concentrate (RUO) | 818M-94-RUO |
| 0.5 mL concentrate (RUO) | 818M-95-RUO |
| 1.0 mL concentrate (RUO) | 818M-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 818M-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 818M-98-RUO |
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